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Cells & behaviour

Subcortical circuitries in sleep & arousal

Area of Research

RGC-trans-synaptically-labelled-with-rabies-SAD-DG-(red),-RGCs-(green)Our overall interest is to investigate the causal link between abnormal neural network assembly and maintenance and the appearance of behavioural traits associated with brain disorders. Particular emphasis is given to subcortical networks regulating the periodic oscillation between the alert, wake state and the sleep state. Our experimental approach relies on the combined application of functional neuroanatomy, genetics and behavioural tests. Ultimately, we aim at providing a mechanistic explanation for circadian rhythm and sleep disorders in humans.




Members of the Delogu Lab


Alessio Delogu, PI

Olivier Brock, Postdoctoral fellow

Polona Jager, PhD student

Hong-Ting Kwok, PhD student

Alastair Kirby PhD student

Anna Kroiss Erasmus visiting student

Gur-Simirun Bagary BSc student

Sanjeev Sharma BSc student

Past members

Lauren Strother, MSc student

Daniel Mensch, Erasmus visiting student

Yao Hui Mao, BSc trainee

Nuo En Julie Chan, BSc trainee



Jager P, Ye Z, Yu X, Zagoraiou L, Prekop HT, Partanen J, Jessell TM, Wisden W, Brickley SG, Delogu A. Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus. Nat Commun. 2016 Dec 8;7:13579. doi:10.1038/ncomms13579.



Transcriptional control of GABAergic neuronal subtype identity in the thalamus. Sellers K, Zyka V, Lumsden AG, Delogu A. Neural Dev. 2014 Jun 15;9(1):14. [Epub ahead of print] PMID: 24929424

NREM and REM Sleep: Complementary Roles in Recovery after Wakefulness. Vyazovskiy VV, Delogu A.
Neuroscientist. 2014 Mar 4. [Epub ahead of print] PubMed PMID:24598308. doi:10.1177/1073858413518152


ETV6/RUNX1 Induces Reactive Oxygen Species and Drives the Accumulation of DNA Damage in B Cells. Neoplasia. 2013 Nov;15(11):1292-300.
Kantner HP, Warsch W, Delogu A, Bauer E, Esterbauer H, Casanova E, Sexl V, Stoiber D. PubMed PMID:24339741;PubMed Central PMCID: PMC3858895.  


Subcortical visual shell nuclei targeted by ipRGCs develop from a Sox14+-GABAergic progenitor and require Sox14 to regulate daily activity rhythms.
Delogu A, Sellers K, Zagoraiou L, Bocianowska-Zbrog A, Mandal S, Guimera J, Rubenstein JL, Sugden D, Jessell T, Lumsden A. Neuron. 2012 Aug 23;75(4):648-62. doi: 10.1016/j.neuron.2012.06.013. PubMed PMID: 22920256.


Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development.
Malin S, McManus S, Cobaleda C, Novatchkova M, Delogu A, Bouillet P, Strasser A, Busslinger M. Nat Immunol. 2010 Feb;11(2):171-9. doi: 10.1038/ni.1827. Epub 2009 Nov 29. PubMed PMID: 19946273; PubMed Central PMCID: PMC2956121.


Her6 regulates the neurogenetic gradient and neuronal identity in the thalamus.
Scholpp S, Delogu A, Gilthorpe J, Peukert D, Schindler S, Lumsden A. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19895-900. doi: 10.1073/pnas.0910894106. Epub 2009 Nov 10. PubMed PMID: 19903880; PubMed Central PMCID: PMC2775703.


Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function.
Schebesta A, McManus S, Salvagiotto G, Delogu A, Busslinger GA, Busslinger M. Immunity. 2007 Jul;27(1):49-63. Epub 2007 Jul 19. PubMed PMID: 17658281.

Pax5: the guardian of B cell identity and function.
Cobaleda C, Schebesta A, Delogu A, Busslinger M. Nat Immunol. 2007 May;8(5):463-70. Review. PubMed PMID: 17440452.


Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells.
Delogu A, Schebesta A, Sun Q, Aschenbrenner K, Perlot T, Busslinger M. Immunity. 2006 Mar;24(3):269-81. PubMed PMID: 16546096.


Derivation of 2 categories of plasmacytoid dendritic cells in murine bone marrow.
Pelayo R, Hirose J, Huang J, Garrett KP, Delogu A, Busslinger M, Kincade PW. Blood. 2005 Jun 1;105(11):4407-15. Epub 2005 Feb 22. PubMed PMID: 15728131; PubMed Central PMCID: PMC1850236.

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