Marc David Ruepp Group
Marc-David Ruepp Group
My research group is interested in RNA metabolism in health and disease with a specific focus on dysfunctional RNA metabolism and neurodegeneration. Our principal objective is to elucidate the molecular basis of selective neuronal death in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). To this end, using CRISPR/Cas9 and TALENs, we have generated a series of isogenic induced pluripotent stem cells harbouring mutations in different genes. We are using these to identify common and, hence, key degenerative pathways responsible for motor neuron death that hopefully can be targeted to modify disease progression, independent of aetiology. Furthermore, based on the conviction that understanding the physiological function(s) of a gene involved in neurodegeneration is valuable to gain insight into potential pathomechanisms, we are interested in elucidating and characterising the functions and RNA targets of Fused in Sarcoma (FUS).