International Parkinson’s Centre of Excellence in Parkinson’s/ Movement Disorders.
Here you will find information about Professor K Ray-Chaudhuri's (also known as Ray Chaudhuri) research group.
The group mainly focuses on high quality clinical and translational work addressing non motor aspects of Parkinson’s disease (PD) regarded and listed as a key unmet need by NICE. The key achievements are highlighted in KCL IoP Case Studies, available from KCL online.
The group has focused on the following research areas:
Setting up an international network of research centres for a combined non motor data registry tracking natural history. This is mediated through two main networks:
1) EUROPAR (European Parkinson's Group)
Led by Prof K Ray Chaudhuri, EUROPAR is a multidisciplinary group that was formed to perform “real life” non-motor based clinical studies across a wide range of people with Parkinson’s throughout Europe. The main aim of EUROPAR is to pursue studies as they happen in real life and described as a "holistic" natural history study in Parkinson's. The study will additionally include people with Parkinson's who are often excluded from clinical trials e.g. due to their age.
EUROPAR focuses on translational ‘bench to bedside’ research (for example, looking at what impact ‘real life’ treatments such as skin patches, injections and infusions may have on the non-motor aspects of Parkinson’s) and the development of better patient and public involvement in the treatment of Parkinson’s disease.
The main EUROPAR project is a longitudinal study in Parkinson’s (NILS: Non-motor Longitudinal International Study), a global study addressing non-motor profiling of Parkinson's and natural history of non-motor symptoms together with treatment response and clinico-pathological correlations. This project has been adopted by the Department of Health in the UK (NIHR: National Institute of Health Research) and also supported by the Spanish ministry of education and the Biomedical Research Centre (Dementia) at King’s College.
EUROPAR involves 14 centres across Europe while the international non motor research group led from King’s involves 34 centres worldwide.
EUROPAR is a partner of European Parkinson’s Disease Association as well as part of International Parkinson’s and Movement Disorders Society Parkinson’s Non Motor Study Group.
2) IPMDS Non Motor Study Group (NM-PD-SG):
In 2012 as part of International Parkinson’s and Movement disorders society a new study group was set up with a chair Prof K Ray Chaudhuri. The Non motor PD Study Group is developing international collaborative research in the field of non motor symptoms in PD. Its goals are:
- To collect new and novel patient and carer reported information on Non-Motor Symptoms (NMS) of Parkinson’s disease from around the world
- To develop a MDS version of a new PD non motor symptoms scale
- To ensure that comprehensive and unified NMS assessments in clinical trials and scientific studies are increasingly used to increase the “real life” value of clinical trials and clinical studies.
- To develop new and novel NMS instruments for use in clinics - PD pain scale (currently in development and validation); Vision scale.
- To set up and start international cross cultural studies, to improve existing tools for NMS (e.g. NMSS and NMSQ)
- To develop animal models addressing non-motor phenotypes of PD
- To refine, validate and establish non-motor subtypes of PD and related biomarkers