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Antipsychotics in Pregnancy

We are currently undertaking research to provide evidence on the risks and benefits of psychotropic drugs in pregnancy through analyses of data from the Case Register Interactive Search (CRIS) system (a unique anonymised secondary care mental health care database).

CRIS allows searching and retrieval of anonymised records from the SlaM Patient Journey System and we are carrying out a retrospective cohort study investigating the risk of and time to relapse during pregnancy, and in the postpartum period, after stopping psychotropic medication compared with continuing medication and compared with switching medication, in pregnant women with a history of psychosis.

We aim to compare outcomes for different types of medications used through pregnancy.  We hope to extend this work in the future to look at maternal physical health and neonatal outcomes.  This project is currently funded by Tommy’s Baby Charity through a grant from Johnson and Johnson.

Who is involved?

The research team includes Professor Louise Howard, Professor Rob Stewart, Clare Taylor and Matthew Broadbent.

The Clinical Records Interactive Search (CRIS) system is funded and developed by the National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London and a joint infrastructure grant from Guy’s and St Thomas’ Charity and the Maudsley Charity.



The prevalence and correlates of self-harm in pregnant women with psychotic disorder and bipolar disorder Taylor, C., van Ravesteyn, L. M., van Denberg, M. P. L., Stewart, R. & Howard, L. 13 May 2016 In : Archives of Women's Mental Health. p. 1-7


The characteristics and health needs of pregnant women with schizophrenia compared with bipolar disorder and affective psychoses Taylor, C. L.Stewart, R.Ogden, J., Broadbent, M., Pasupathy, D. & Howard, L. M. 17 Apr 2015 In : BMC Psychiatry. 15, , 88

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