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NIHR - Wellcome Trust Clinical Research Facility

NIHR - Wellcome Trust King's Clinical Research Facility

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A 3Tesla GE Healthcare MR750 MRI scanner was commissioned and installed in the summer of 2011, and was specified to provide state-of-the-art MR imaging modalities in all areas of clinical research.  For this purpose, it has been equipped with RF coils for neuro (brain, cerebro-vascular and spine), abdominal and extremity imaging.  In addition, the scanner also includes capabilities for multi-nuclear spectroscopy (1H, 13C and 31P).

The primary clinical target of this unit is the application of MRI to the study of acute and chronic presentations of traumatic brain injury (head trauma, stroke and tumour).  To facilitate this, the unit is also equipped with all devices necessary to monitor and maintain anaesthetised patients while scanning.  Neuro-applications are a primary research objective of this unit; to this aim the scanner has capability for high-speed, high-resolution Functional Imaging, Diffusion Tensor Imaging, MR Angiography and Arterial Spin Labelling.

 

Clinical Preparation Area

The MRI Unit has its own, dedicated Clinical Preparation Room, equipped with all facilities necessary for clinical assessment of patients and healthy control subjects prior to and after scanning. Another target area for this unit is the application of MR imaging technology to the characterisation of candidate psychoactive compounds. The room has access to the MRI scanning suite via a dedicated RF screened hatch, incorporated into the room’s RF shield, in order to collect blood samples from subjects whilst being scanned. The room also houses a high-speed centrifuge and a -20C freezer for short-term storage of serum samples for subsequent analysis.

 

Interview and image processing rooms

Adjacent to the unit there is a room for interviewing, screening and training of subjects before and/or after scanning.  A dedicated team is in charge of implementing software programs for administration of sensory and cognitive paradigms for functional imaging.  A very large range of hand held devices (button boxes, joysticks, pressure sensitive controls, etc.), have been built for the execution of such functional paradigms in the scanner.

 

Access

The scanner is administered by the Neuroimaging Department of King’s College London; encompassed within the College’s Major Research Imaging Facility.  Access procedures for the CRF MRI scanner are the same as for the other MRI scanners within the Department.  After contacting the Clinical Research Facility Manager, Elka Giemza to discuss undertaking your project at the CRF, please address specific imaging issues to:

For details of scanning modalities and protocol design: Dr Fernando Zelaya

For scanning costings, click here

Please note: scanning costings should be approved prior to the submission of grant applications for funding, prior to/during contract negotiations.

For advice on ethics and regulatory issues: Professor Gareth Barker          

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