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Preclinical Imaging Unit

Preclinical Imaging Unit

The BRAIN Centre

Biomarker Research And Imaging for Neuroscience

Our newly refurbished preclinical imaging center is set up to facilitate the development and optimization of translational biomarkers of neurological & psychiatric disorders via a team of dedicated scientists and state of art equipment.

We aim to develop and apply in vivo and ex vivo imaging and corroborative methods to understand pathological mechanisms underlying various diseases, engendering innovative strategies for successful therapeutic interventions.

Quantitative high-resolution imaging is a powerful aid to diagnosing and staging of diseases, as well as therapeutic monitoring, paving the way towards personalized medicine. In particular, the use of non-invasive methods such as MRI and MRS allows rapid transfer of basic scientific findings to the clinic. Here, the translation of imaging methods between preclinical and clinical arenas is enhanced by the presence of BRAIN Centre along with our Clinical imaging facilities in the same Department of Neuroimaging.

The BRAIN Centre provides capabilities to investigate various disease models, especially of neuro-psychiatric disorders that are a major focus of the Department of Neuroimaging. Thus, the Department of Neuroimaging, uniquely, encompasses and fosters both fundamental and clinical imaging research. This multifaceted approach enhances our understanding of the pathophysiological mechanisms underlying disease, as well as assists the development of novel therapeutic interventions.

The Facility

7T scanner

The BRAIN Centre houses state-of-the-art purpose built suite for preclinical experimental research. At the end of 2016, we installed a new Bruker 9T horizontal MR scanner with adjoining dedicated ancillary services, fully equipped to study anatomical, metabolic and functional aspects of experimental models of disease. The scanner has similar capabilities to the Department’s clinical scanners, including the ability to undertake structural, functional and quantitative (diffusion, perfusion and relaxometry) imaging, but accommodates smaller subjects and objects and can achieve significantly higher resolution.

The BRAIN Centre also houses laboratory suites furnished for investigations into experimental models of disease. Associated with the BRAIN Centre are other imaging and non-imaging laboratories e.g. for EEG, Laser Doppler, autoradiography (14C and 3H), microscopy, behavioural testing, histology and tissue/cell culture facilities. 

 

Staff

Dr Diana Cash - Centre Manager

Dr Camilla Simmons - Operations & Biological services Manager

 

Bookings

Prospective users should contact brain@kcl.ac.uk to discuss your requirements and how best we can accommodate your project(s) in the BRAIN Centre. For more information please visit us at https://brain-imaging.org

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