Contact the Centre for Affective Disorders
Who we are:
Prof Allan Young, Professor in Mood Disorders, Director, Centre for Affective Disorders
Research interests: cause and treatments for severe psychiatric illnesses, particularly mood disorders
Prof Anthony Cleare Professor of Psychopharmacology & Affective Disorders and Head of the Affective Disorders Research Group
Research interests: Clinical psychopharmacology; neuroendocrinology and neurochemistry and functional neuroimaging (PET and f-MRI) of depression, chronic fatigue syndrome and aggression; neuroimaging of serotonin receptor function; biological effects of psychological therapies
Prof Carmine Pariante Professor of Biological Psychiatry and Head of Stress, Psychiatry and Immunology Laboratory & Section of Perinatal Psychiatry
Research interests: investigates the role of stress in the pathogenesis of mental disorders and in the response to psychotropic drugs, both in clinical samples and experimental settings. His work focuses on depression and fatigue, with a particular interest in the perinatal period and in subjects with medical disorders. Moreover, he also uses animal and cellular models.
Dr Sameer Jauhar, Senior Research Fellow
Dr Jauhar's research interests focus on understanding neurobiological causes of psychotic illness, with a focus on the affective psychoses, and treatment of psychotic and affective illnesses.
Dr Mario Juruena, Clinical Senior Lecturer in Translational Psychiatry
Dr Juruena is a Clinical Senior Lecturer in Translational Psychiatry, and leads the Maudsley Advance Treatment Service- MATS, which works to develop new treatments for treatment-resistant depression and treatment-resistant bipolar disorder. His lab seeks to understand the essential triggers of treatment-resistant affective disorders, and improve clinical treatments and patient response, developing clinical trials for new targets in pharmacotherapy and neuromodulation, novel clinical assessment tools and translation of our research findings into novel treatments. His lab has been interested in developing biomarkers, genetics, neuroimage and neuroendocrine factors, running this Translational Psychiatry Research Programme, he has been studying the connections between stress, mainly early life stress, the neuroendocrine axis and impaired cognition in treatment-resistant affective disorders.
Dr Adam Perkins, Lecturer in the Neurobiology of Personality
Research interests: to explain why some people are more prone to anxiety than others with a view to explaining the causes, and improve the treatment of, anxiety and depression-related illnesses.
Dr James Rucker, NIHR Clinician Scientist
Focusses on clinical trials using the psychedelic drug psilocybin (‘magic’ mushrooms) the empathogen MDMA (‘ecstacy’) and the cannabinoids as treatments for resistant forms of mood, anxiety and trauma response problems in combination with psychotherapy. The lab is called the ‘Psychedelic Trials Group’ (PTG) and is formed of research assistants, junior psychiatrists, psychological therapists and research nurses, who undertake recruitment, assessment, dosing and follow up. We have a strategic partnership with COMPASS Pathways Ltd., and MAPS Europe PLC, who manufacture psilocybin and MDMA respectively to the standard required for clinical trials. The PTG also organises a series of public facing events, patient surveys and engagement exercises to build a case for new trials using psilocybin and MDMA-assisted therapy and cannabinoids in a wide range of psychiatric problems, e.g. functional neurological disorders, eating disorders, PTSD, anxiety disorders, palliative care scenarios, chronic pain and other disorders at the interface of psychiatry, neurology and the rest of medicine. The overall aim of the PTG is to inform the evidence base surrounding the medical utility of drugs that, hitherto, have been under-investigated due to legal restrictions on use but were previously used in medicine.
Dr Paul Stokes, Clinical Senior Lecturer in Mood Disorders & Honorary Consultant Psychiatrist, South London & Maudsley NHS Trust
Uses MRI neuroimaging to understand the brain mechanisms underlying reward and cognitive symptoms in mood disorders, and to identify how potential new treatments effect brain function. We evaluate the best ways of treating mood disorders by using clinical trials and meta-analyses methodologies and have a particular interest in treatment-resistant bipolar depression and addiction co-morbidity. Finally, we use the CRIS clinical record system to understand the diagnostic differences (for example unipolar mania) and treatment challenges experienced by people with mood disorders.
Dr Roland Zahn, Senior Clinical Lecturer in the Neurocognitive Bases of Mood Disorders, MRC Clinician Scientist Fellow & Honorary Consultant Psychiatrist, South London and Maudsley Trust
Focusses on the translational cognitive neuroscience of affective disorders by employing methods including phenomenological psychopathology, mobile technology, virtual reality, neuropsychology, neuroimaging, neuromodulation, neurofeedback, machine learning-based prediction modelling, as well as computerised decision support systems. The overall aim is to use cognitive-anatomical models of organic and non-organic mood disorders to develop novel personalised treatments, algorithms, and diagnostic systems.
Dr Patricia Zunszain, Senior Lecturer in Neuroscience of Mental Health Education
Dr Zunszain's research focuses on elucidating underlying mechanisms of mood disorders. She uses cellular models to mimic brain function as well as saliva and blood clinical samples to study different psychiatric disorders in collaboration with other teams, looking for biomarkers that can follow disease and predict response. The ultimate aim of her research is to provide a basis for improved treatment. She has a particular interest in the role of inflammation and stress in depression, and is now studying the role of oxidative stress as a model to describe molecular changes underlying depression as well as neurodegeneration, with the expectation to provide new pharmacological targets to design more effective medications.
The Centre for Affective Disorders has a number of visiting academics;
Prof Cindy Fu, Professor in Affective Neuroscience, University of East London
She trained in psychiatry at the University of Toronto, where she was the Chief Resident at the Clarke Institute of Psychiatry (now Centre for Addiction and Mental Health). She was a Wellcome Fellow and completed her PhD in 2004 at the Institute of Psychiatry, King’s College London.
Dr Ilaria Galizia, University of Bari, Italy
Professor John Harrison, Associate Professor at VU University Medical Center - Amsterdam Neuroscience & Principal Consultant at Metis Cognition Ltd
Prof Gavin Reynolds, Honorary Professor of Neuroscience, Sheffield Hallam University & Professor Emeritus at Queen’s University Belfast
Research interests: understanding changes in the brain in schizophrenia and other psychiatric disorders, identifying abnormalities in neurotransmitter systems. Investigating the mechanisms underlying both the wanted and adverse effects of the antipsychotic drugs used to treat schizophrenia.
Prof Jan Scott, Emeritus Professor of Psychological Medicine
Jan Scott is Professor of Psychological Medicine at the University of Newcastle, and has recently been appointed to the post of Chaire d'Excellence with Fondation Fondamental and the Center Expert Bipolaire with the Universite-Paris-Est-Creteil, in France. She is an Honorary Professor at the Institute of Psychiatry and a Distinguished Founding Fellow of the Academy of Cognitive Therapy.
Professor Scott trained in psychiatry in Newcastle upon Tyne and was then a professor in Glasgow and the Institute of Psychiatry in London, before returning to Newcastle. Professor Scott also held visiting academic posts with Aaron Beck at the Penn State University in Philadelphia, Eugene Paykel at Cambridge University, and Eduard Vieta in Barcelona and was also awarded the RCPsych travelling scholarship to Johns Hopkins University, Baltimore.
PA to Prof Allan Young
Telephone: +44 (0) 20 7848 0088
Centre for Affective Disorders
Institute of Psychiatry, Psychology & Neuroscience
King's College London
PO72 De Crespigny Park
London, SE5 8AF
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