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Research group

Irritable Bowel Syndrome

Overview

Irritable Bowel Syndrome (IBS) affects 10–22% of the UK population. Current treatment relies on a positive diagnosis, reassurance, lifestyle advice and drug therapies, but many suffer on-going symptoms.

Professor Moss-Morris has developed a CBT based self-management manual for treating IBS in primary care with minimal therapist contact.   In collaboration with colleagues in Southampton, and funded through NIHR RfPB, a web version of this treatment approach was developed called Regul8. Publications from modelling work for the intervention and trials of the approaches are listed below.

  • Everitt, H., Landau, S., Little, P., Bishop, F.L., McCrone, P., O'Reilly, G., Coleman, N., Logan, R., Chalder, T., Moss-Morris, R,. ACTIB trial team. (2015). Assessing Cognitive behavioural Therapy in Irritable Bowel (ACTIB): protocol for a randomised controlled trial of clinical-effectiveness and cost-effectiveness of therapist delivered cognitive behavioural therapy and web-based self-management in irritable bowel syndrome in adults. BMJ Open, 5(7). doi: 10.1136/bmjopen-2015-008622.
  • Chilcot, J. and Moss-Morris, R. (October 2013). Changes in illness-related cognitions rather than distress mediate improvements in irritable bowel syndrome (IBS) symptoms and disability following a brief cognitive behavioural therapy intervention. Behaviour Research and Therapy, 51 (10) 690-695 DOI: 10.1016/j.brat.2013.07.007
  • Moss-Morris, R., & Spence, M.   (2006). To “lump” or to “split” the Functional Somatic Syndromes: Can infectious and emotional risk factors differentiate between the onset of chronic fatigue syndrome and irritable bowel syndrome? Psychosomatic Medicine, 68(3), 463-469. doi:10.1097/​01.psy.0000221384.07521.05
  • Spence, M., & Moss-Morris, R. (2007). The cognitive behavioural model of irritable bowel syndrome: a prospective investigation of gastroenteritis patients. GUT, 56(8), 1066-1071. doi:10.1136/gut.2006.108811
  • Moss-Morris, R., Bogalo, L., Didsbury, L. P., & Spence, M.J.  (2010). A randomised controlled trial of a cognitive behavioural therapy based self-management intervention for irritable bowel syndrome (IBS) in primary care. Psychological Medicine,  40(1), 85-94. doi:10.1017/S0033291709990195
  • Everitt, H. A., Moss-Morris, R., Sibelli, A., Tapp, L., Coleman, N. S., Yardley, L., Smith, P. W., & Little, P. S. (2010). Management of Irritable Bowel Syndrome in Primary Care: Feasibility Randomised Controlled trial of mebeverine, methylcellulose, placebo and a patient self-management cognitive behavioural therapy website. (MIBS trial). BMC Gastroenterology 2010, 10(136), 1-9. Retrieved from: http://www.biomedcentral.com/1471-230X/10/136
  • Everitt, H. A., Moss-Morris, R., Sibelli, A., Tapp, L., Coleman, N., Yardley, L., Smith, P., & Little, P. S. (2013). Management of irritable bowel syndrome in primary care: the results of an exploratory randomised controlled trial of mebeverine, methylcellulose, placebo and a self-management website. BMC Gastroenterology, 13(68). doi:10.1186/1471-230X-13-68

In collaboration with colleagues in Southampton we are conducting an HTA NIHR funded study.

ACTIB (Assessing Cognitive behavioural Therapy in Irritable Bowel): A randomised controlled trial of clinical and cost effectiveness of therapist delivered cognitive behavioural therapy and web-based self-management in irritable bowel syndrome.

To date, ACTIB, when completed, will be the largest trial worldwide to address the clinical-effectiveness and cost-effectiveness of cognitive behaviour therapy for irritable bowel syndrome and has the advantage of comparing a low intensity web-based CBT with a higher intensity telephone therapist delivered CBT.

IoPPN STAFF (Section of Health Psychology)

Prof Rona Moss-Morris

Other ACTIB  IoPPN Collaborators

Prof. Trudie Chalder

Prof. Paul McCrone

Prof Sabine Landau

Caroline Murphy

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