Prof. Peter McGuffin: A Tribute
Professor Peter McGuffin is a clinical psychiatrist whose research background and training is in the genetics of common disorders and behaviours. In late 2013, he retired from his post as honorary consultant psychiatrist in the South London & Maudsley Trust's Affective Disorders Service and became an Emeritus Professor at the MRC SGDP Centre. This film is a tribute to his work:
Professor McGuffin attended medical school at the University of Leeds, England where he graduated in 1972 and then received postgraduate training in internal medicine. It was at this stage that he became interested in genetics and had his first publications on immunogenetic aspects of coronary heart disease. He transferred this interest to psychiatric disorders and carried out one of the first genetic marker association studies on schizophrenia.
He completed his training as a psychiatrist at the Maudsley Hospital, London and was awarded a Medical Research Council Fellowship to study genetics at the University of London and at Washington University in St Louis, Missouri. He subsequently became an MRC Senior Clinical Fellow at the Maudsley and the Institute of Psychiatry and then took up the Chair of Psychological Medicine at the University of Wales College of Medicine in Cardiff in 1987. He succeeded Prof Sir Michael Rutter as Director of the MRC Social, Genetic and Developmental Psychiatry Centre at the Institute of Psychiatry in October 1998 till December 2006. From January 2007 to December 2009 he was the Dean of the IoP. He returned as Director of the Centre from 2010 to 2012.
Final Lecture at the MRC SGDP Centre:
On Oct 23rd 2013, shortly prior to his retirement at the end of the year, Professor McGuffin gave his final lecture on:
"Some clinical implications of the work of the MRC Social, Genetic & Developmental Psychiatry Centre"
Lecture Abstract:- The MRC Social, Genetic & Developmental Psychiatry (SGDP) Centre is considered to be one of the basic science departments within King’s Health Partners but I will argue that much of what we do has immediate and direct relevance for clinical practice, and I will give examples relating mainly to depression. I will start with the basic question of ‘what is a disease? - and does depression qualify as such?’ I will then go on to address two contemporary concerns: that the treatments don’t work and that they may even make you worse. I will then give an update on work here and by others on using a combination of genetics, ’omics and refined clinical assessment to predict treatment response and make progress on the path to stratified/personalised psychiatry.