Course 2- Polygenic Risk Score Analyses
This course will take place on Friday 21st June 2019
Dr Paul O'Reily Dr Sam Choi
This one-day workshop will describe some of the fundamental theory underpinning polygenic risk score (PRS) analyses, provide hands-on practical sessions illustrating both basic and more complex PRS analyses, and illustrate the application of PRS using examples from published and ongoing research. We will use our PRSice software in computer practicals but will also describe how the same kind of analyses can be performed with alternatives (eg. LDpred). Topics covered will include: QC, pruning/clumping, the sample overlap problem, estimating pseudo-R2, ascertainment, multi-ethnic PRS, over-fitting, shrinkage methods, PRS for G*G/G*E and the potential for PRS to contribute to clinical prediction and Personalised Medicine.
Who is it for:
Anyone who is planning to perform Polygenic Risk Score analyses in the future for the first time, as well as those who have previously performed such analyses but feel they would like training on the more technical and advanced aspects.
How is the course taught:
A mixture of lectures and computer practicals
What will I get out of it:
A comprehensive basic training in the theory and application of Polygenic Risk Scores, as well as more advanced training focused in areas of the directors’ recent research on the topic.
Preliminary timetable for the day:
09:00 - 10:00 (Optional) Introduction to programming
10:00 - 11:15 PRS theory, main applications and PRSice
11:15 - 11:45 Coffee & Questions
11:45 - 13:00 Practical Session I: standard PRSice applications
13:00 - 14:00 Lunch
14:00 - 15:15 Advanced PRS theory and applications
15:15 - 15:45 Coffee & Questions
15:45 - 17:00 Practical Session II: advance PRSice applications
The full fee for the course is £250
Discounted fees are available for the following groups:
Public Sector workers £150
Students at other institutions £150
King's students £75
King's staff / King's health partners and SLAM employee's £75
If you are unsure which rate you need to pay please contact: SummerSchoolSGDP@kcl.ac.uk
This course is CPD approved
Applications opening soon!