Bioinformatics at the Wolfson CARD
The recent explosion of data in the biological sciences driven by advancements in molecular biological technologies has made bioinformatics an integral part of biological research. At the Wolfson CARD bioinformatics covers research in structural biology and rational drug design as well as computational and theoretical approaches to database analysis.
The big challenge addressed is to integrate the vast amount of deposited freely available biological data into a predictive framework for generating novel hypotheses to inform experiment and to identify drug targets. Once target proteins have been validated the challenge then is to characterise the structural aspects of the protein interaction and then design modulators either based on mimetics of peptide fragments or in silico screening of compound libraries.
The Williams's Lab work covers many areas of bioinformatics with particular emphasis on structural biology. Current projects are microarray search engines, protein dynamical simulation and interaction site prediction.