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Pain

Pain

PainChronic pain is a debilitating disorder that affects millions of people world-wide and has a considerable detrimental impact on quality of life. There are multiple events which can lead to chronic pain including trauma, diabetes, surgical procedures, cancer and HIV. Effective analgesic therapies are inadequate in the majority of chronic pain patients and are often associated with unpleasant side-effects. Consequently at present there is a substantial, unmet, clinical need for more effective analgesics for chronic pain patients.

The pain group is led by Professor Stephen McMahon and Professor Marzia Malcangio

Pain, Injury and Repair of the Damaged Nervous System

Professor Stephen McMahon

Plasticity of the first pain synapse laboratory

Professor Marzia Malcangio
We study neuronal and immune cell-mediated mechanisms regulating the strength of sensory neuron-dorsal horn neuron synapse in the spinal cord to reveal new targets for chronic pain treatment.

Molecular and cellular basis of thermal sensation and pain

Professor Peter McNaughton

Peter McNaughton’s group study how heat, cold and pain are detected in sensory neurons and how processes at the molecular level impact on pain and thermal sensation at the level of the whole animal. They have two drug discovery programs aiming to find blockers of ion channels important in pain.

Pain caused by chemotherapy or surgery

Dr Sarah Flatters
Our research focuses on chemotherapy-induced painful peripheral neuropathies and persistent postoperative pain. Pre-clinical and clinical studies are examining the causal mechanisms and novel treatments for these chronic pain states.

TRPV4

Dr Andy Grant
I am investigating TRPV4 activation in chronic neuropathic and inflammatory pain, to determine mechanisms of sensitisation

Modeling pain in vitro

Dr Ramin Raouf

We are developing cell culture models that can faithfully recapitulate the biology of the pain system. We use these in vitro  models to investigate the  molecular basis of pathological pain.  

Mechanisms of sensory transduction and transmission

Professor Stuart Bevan
Our laboratory studies sensory transduction and transmission in peripheral sensory neurons in order to understand some of the cellular and molecular processes that underlie nociception and analgesia.

Ionic sensory transduction mechanisms

Dr David Andersson

Transient receptor potential (TRP) ion channels are essential transduction molecules that convert chemical and physical information into electrical and ionic signals. My work is focused on how TRP channels contribute to sensory neuron transduction mechanisms

 

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