Chronic pain is a debilitating disorder that affects millions of people world-wide and has a considerable detrimental impact on quality of life. There are multiple events which can lead to chronic pain including trauma, diabetes, surgical procedures, cancer and HIV. Effective analgesic therapies are inadequate in the majority of chronic pain patients and are often associated with unpleasant side-effects. Consequently at present there is a substantial, unmet, clinical need for more effective analgesics for chronic pain patients.
The pain group is led by Professor Stephen McMahon and Professor Marzia Malcangio
Pain, Injury and Repair of the Damaged Nervous System
Professor Stephen McMahon
Plasticity of the first pain synapse laboratory
Professor Marzia Malcangio
We study neuronal and immune cell-mediated mechanisms regulating the strength of sensory neuron-dorsal horn neuron synapse in the spinal cord to reveal new targets for chronic pain treatment.
Molecular and cellular basis of thermal sensation and pain
Professor Peter McNaughton
Peter McNaughton’s group study how heat, cold and pain are detected in sensory neurons and how processes at the molecular level impact on pain and thermal sensation at the level of the whole animal. They have two drug discovery programs aiming to find blockers of ion channels important in pain.
Pain caused by chemotherapy or surgery
Dr Sarah Flatters
Our research focuses on chemotherapy-induced painful peripheral neuropathies and persistent postoperative pain. Pre-clinical and clinical studies are examining the causal mechanisms and novel treatments for these chronic pain states.
Dr Andy Grant
I am investigating TRPV4 activation in chronic neuropathic and inflammatory pain, to determine mechanisms of sensitisation
Modeling pain in vitro
Dr Ramin Raouf
We are developing cell culture models that can faithfully recapitulate the biology of the pain system. We use these in vitro models to investigate the molecular basis of pathological pain.
Mechanisms of sensory transduction and transmission
Professor Stuart Bevan
Our laboratory studies sensory transduction and transmission in peripheral sensory neurons in order to understand some of the cellular and molecular processes that underlie nociception and analgesia.
Ionic sensory transduction mechanisms
Dr David Andersson
Transient receptor potential (TRP) ion channels are essential transduction molecules that convert chemical and physical information into electrical and ionic signals. My work is focused on how TRP channels contribute to sensory neuron transduction mechanisms