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Andersson Lab

About the Andersson Lab

Research in David Andersson’s laboratory is centred on sensory transduction mechanisms, TRP channels and their importance for normal physiology and chronic pain conditions. Our current investigations are focused on complex regional pain-syndrome (CRPS), diabetic sensory neuropathy, chemotherapy induced pain, as well as normal sensory transduction mechanisms. We explore each of these research questions using combinations of behavioural investigations (in vivo), electrophysiological and microfluorimetric methods, supported by molecular and biochemical techniques. More details about the ongoing projects can be found at our research pages.

Chronic pain of different aetiologies represents a major unmet clinical need, since the available therapies fail to provide satisfactory pain relief for many patients. Identification of novel potential therapeutic targets and an improved understanding of the mechanisms involved in nociception and chronic pain are therefore urgently needed. We have earlier identified the cold-sensitive ion channel TRPM8 as a sensory receptor for physiologically relevant osmolality and we further demonstrated that tear fluid osmolality controls eye-blinking by modulating TRPM8. We have also discovered that the widely used paracetamol elicits analgesia and hypothermia by stimulating TRPA1 and we have identified

endogenous agonists and modulators for TRPA1 (Zn2+, oxidative stress, H2S and methylglyoxal) and TRPM8 channels (lipids, pH).

Our current projects are supported by the Medical Research Council, BBSRC LIDO and the Pain Relief Foundation.

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