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Andreou Lab

About the Headache Research Lab

headache research hero

Research focus

The Headache Research Lab focuses on the neurobiology of primary and secondary headaches and in developing novel therapies to prevent headaches. Although many advances have been achieved around the neurobiology of headaches over the past decade, their actual pathophysiology remains unclear. Most importantly, the available treatments for patients are largely ineffective with further socioeconomic impacts. Understanding the pathological and cellular events that occur before and after a headache attack and targeting these with novel, disease-specific therapies is the main goal of the Andreou Lab.

Our research spans two main themes:

1. Mechanistic research into understanding disease biology and processes at the cellular and molecular level

  • Investigation of the role of novel ion channels in the trigeminovascular system
  • Investigation of sensory brain pathways involved in migraine, trigeminal autonomic cephalalgias’ (TACs) pathophysiology and facial pain
  • Proteomics/ novel targets and biomarkers/ drug discovery

2. Translational research aimed at developing promising therapies to prevent and treat primary headaches, and understanding the mechanism of action of current treatments

  • Identifying novel, targeted preventive treatments for migraine, TACs and facial pain with less side effects
  • Investigation of the mechanism of action of neuromodulation techniques in headaches treatment
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