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Hobbs Research


  • J. Dawes, D Bennett, M Calvo, T Kaan, C Orengo, H Kiesewetter, K Paterson, J Perkins C,Hobbs, S McMahon. The use of UVB irradiation as a translational pain model reveals CXCL5 as a pain mediator. Science Translational Medicine.  In press
  • Stephens AS, Stephens SR, Hobbs C, Hutmacher DW, Bacic-Welsh D, Woodruff MA,Morrison NA. (2011).  Myocyte enhancer factor 2C: an osteoblast transcription factor identified by DMSO enhanced mineralization. J Biol Chem. Jun 7. [Epub ahead of print]
  • Johnson M, Ekonomou A, Hobbs C, Ballard CG, Perry RH, Perry EK.(2010).  Neurogenic marker abnormalities in the hippocampus in dementia with Lewy bodies.Hippocampus. Jul 21. doi: 10.1002/hipo.20826. [Epub ahead of print]
  • Gao Y, Vasilyev DV, Goncalves MB, Howell FV, Hobbs C, Reisenberg M, Shen R, Zhang MY, Strassle BW, Lu P, Mark L, Piesla MJ, Deng K, Kouranova EV, Ring RH, Whiteside GT, Bates B, Walsh FS, Williams G, Pangalos MN, Samad TA, Doherty P. (2010).   Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice. J Neurosci. Feb 10;30(6):2017-24.
  • Moffitt H, McPhail GD, Woodman B, Hobbs C, Bates GP (2009). Formation of polyglutamine inclusions in a wide range of non-CNS tissues in the HdhQ150 knock-in mouse model of Huntington's disease. PLoS One. Nov 30;4(11)
  • Smith MM, Fraser GJ, Chaplin N, Hobbs C, Graham A. (2009) Reiterative pattern of sonic hedgehog expression in the catshark dentition reveals a phylogenetic template for jawed vertebrates. Proc Biol Sci. Apr 7;276(1660):1225-33.
  • Lai MK, Tan MG, Kirvell S, Hobbs C, Lee J, Esiri MM, Chen CP, Francis PT. (2008). Selective loss of P2Y2 nucleotide receptor immunoreactivity is associated with Alzheimer's disease neuropathology. J Neural Transm. Aug;115(8):1165-72.
  • Watson S, Chambers D, Hobbs C, Doherty P, Graham A. (2008). The endocannabinoid receptor, CB1, is required for normal axonal growth and fasciculation. Mol Cell Neurosci. May;38(1):89-97.
  • Cosker KE, Shadan S, van Diepen M, Morgan C, Li M, Allen-Baume V, Hobbs C, Doherty P, Cockcroft S, Eickholt BJ (2008). Regulation of PI3K signalling by the phosphatidylinositol transfer protein PITPalpha during axonal extension in hippocampal neurons. J Cell Sci. Mar 15;121(Pt 6):796-803.
  • Holzbaur EL, Howland DS, Weber N, Wallace K, She Y, Kwak S, Tchistiakova LA, Murphy E, Hinson J, Karim R, Tan XY, Kelley P, McGill KC, Williams G, Hobbs C, Doherty P, Zaleska MM, Pangalos MN, Walsh FS. (2006).   Myostatin inhibition slows muscle atrophy in rodent models of amyotrophic lateral sclerosis. Neurobiol Dis. Sep;23(3):697-707.
  • Bisogno T, Howell F, Williams G, Minassi A, Cascio MG, Ligresti A, Matias I, Schiano-Moriello A, Paul P, Williams EJ, Gangadharan U, Hobbs C, Di Marzo V,Doherty P. (2003).   Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. J Cell Biol. Nov 10;163(3):463-8.
  • McCormick D, Chong H, Hobbs C, Datta C, Hall PA. (2002). Detection of the Ki-67 antigen in fixed and wax-embedded sections with the monoclonal antibody MIB1. Histopathology. Sep;41(3A):173-8.
  • Walsh FS, Hobbs C, Wells DJ, Slater CR, Fazeli S. (2000). Ectopic expression of NCAM in skeletal muscle of transgenic mice results in terminal sprouting at the neuromuscular junction and altered structure but not function. Mol Cell Neurosci. Mar;15(3):244-61.
  • Davies SW, Sathasivam K, Hobbs C , Doherty P, Mangiarini L, Scherzinger E,Wanker EE, Bates GP. (1999).   Detection of polyglutamine aggregation in mouse models.  Methods Enzymol. 309:687-701.
  • Sathasivam K, Hobbs C, Mangiarini L, Mahal A, Turmaine M, Doherty P, Davies, SW, Bates GP. (1999). Transgenic models of Huntington's disease. Philos Trans R Soc Lond B Biol Sci. Jun 29;354(1386):963-9.
  • Sathasivam K, Hobbs C, Turmaine M, Mangiarini L, Mahal A, Bertaux F, Wanker EE, Doherty P, Davies SW, Bates GP. (1999).   Formation of polyglutamine inclusions in non-CNS tissue. Hum Mol Genet. May;8(5):813-22.
  • Raguz S, Hobbs C, Yagüe E, Ioannou PA, Walsh FS, Antoniou M. (1998). Muscle-specific locus control region activity associated with the human desmin gene. Dev Biol. Sep 1;201(1):26-42.
  • Sundaresan V, Roberts I, Bateman A, Bankier A, Sheppard M, Hobbs C, Xiong J, Minna J, Latif F, Lerman M, Rabbitts P. (1998). The DUTT1 gene, a novel NCAM family member is expressed in developing murine neural tissues and has an unusually broad pattern of expression. Mol Cell Neurosci. May;11(1-2):29-35.
  • Cavuslu S, Goodlad J, Hobbs C, Connor AM, Raju KS, Best JM, Cason J. (1997). Relationship between human papillomavirus infection and overexpression of p53 protein in cervical carcinomas and lymph node metastases. J Med Virol. Oct;53(2):111-7.
  • Caldwell CJ, Hobbs C, McKee PH. (1997). The relationship of Ki67 and involucrin expression in proliferative, pre-neoplastic and neoplastic skin. Clin Exp Dermatol. Jan;22(1):11-6.
  • Fazeli S, Wells DJ, Hobbs C, Walsh FS. (1996).   Altered secondary myogenesis in transgenic animals expressing the neural cell adhesion molecule under the control of a skeletal muscle alpha-actin promoter. J Cell Biol. Oct;135(1):241-51.
  • Mansoor A, McKee PH, Simpson JA, McGuire B, Hobbs C. (1996). Prognostic significance of Ki-67 and p53 immunoreactivity in cutaneous squamous cell carcinomas. Am J Dermatopathol. Aug;18(4):351-7.
  • Vora AJ, Perry ME, Hobbs C, Dumonde DC, Brown KA. (1995).  Selective binding of peripheral blood lymphocytes to the walls of cerebral vessels in frozen sections of human brain. J Immunol Methods. Mar 27;180(2):165-80.
  • Tan SH, Derrick E, McKee PH, Hobbs C, Ridley M, Neill S. (1994).  Altered p53 expression and epidermal cell proliferation is seen in vulval lichen sclerosus. J Cutan Pathol. 1994 Aug;21(4):316-23.
  • Proby CM, du Peloux Menagé H, McGregor JM, Hobbs C, Norris PG, Smith N, Hawk JL, McKee PH. (1993).  p53 immunoreactivity in cutaneous PUVA tumors is similar to that in other non-melanoma skin neoplasms. J Cutan Pathol. Oct;20(5):435-41. P
  • McKee PH, Hobbs C, Hall PA. (1993).  Antigen retrieval by microwave irradiation lowers immunohistological detection thresholds. Histopathology. Oct;23(4):377-9.
  • McCormick D, Yu C, Hobbs C, Hall PA. (1993).  The relevance of antibody concentration to the immunohistological quantification of cell proliferation-associated antigens. Histopathology. Jun;22(6):543-7.
  • McCormick D, Chong H, Hobbs C, Datta C, Hall PA. (1993).  Detection of the Ki-67 antigen in fixed and wax-embedded sections with the monoclonal antibody MIB1. Histopathology. Apr;22(4):355-60.
  • Slater SD, McGrath JA, Hobbs C, Eady RA, McKee PH. (1992).  Expression of mutant p53 gene in squamous carcinoma arising in patients with recessive dystrophic epidermolysis bullosa. Histopathology. Mar;20(3):237-41.
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