Show/hide main menu

News

News Highlights

Treatment cuts migraine days by half

Posted on 30/11/2017
migraine

A new King’s College London study, published in the New England Journal of Medicine (NEJM), shows treatment with a drug called erenumab cut the number of days with migraine symptoms for 50 per cent of patients.

Across the UK, an estimated 8.5 million people live with migraine and research suggests the condition is likely to impact the lives of almost 200,000 people every day.

There is an urgent need for new treatment options and erenumab is the first and only fully human monoclonal antibody of its kind designed to specifically prevent migraine. It works by blocking the calcitonin gene-related peptide (CGRP) receptor, which plays a critical role in migraine activation.

Amgen and Novartis, the codevelopers of erenumab, funded this Phase III STRIVE study.

‘STRIVE is the first fully reported Phase III study of the CGRP pathway monoclonal antibodies, and it clearly shows that blocking this pathway can reduce the impact of migraine,’ said Peter Goadsby, Director, NIHR-Wellcome Trust King’s Clinical Research Facility and Professor of Neurology at King’s College London. ‘The results of STRIVE represent a real transition for migraine patients from poorly understood, repurposed treatments, to a specific migraine-designed therapy. STRIVE, as with the monoclonal antibody developments generally, represents an incredibly important step forward for migraine understanding and migraine treatment.’

These data show erenumab can significantly reduce the number of monthly migraine days experienced by patients, with a 3.7-day and 3.2-day reduction with erenumab 140 mg and 70 mg, respectively, from a baseline of 8.3-days (1.8-day reduction with placebo). Additionally, 50 per cent of patients treated with erenumab 140 mg had the number of days with migraine symptoms cut by at least half (this figure was 43.3 per cent following treatment with erenumab 70 mg, and 26.6 per cent with placebo). Results from the Migraine Physical Function Impact Diary (MPFID) show patients treated with erenumab also reported improved physical health and ability to participate in daily activities over the six month trial period. Erenumab has also been shown to be effective and tolerable over the long term with a safety profile comparable to placebo.

'Migraine is too often trivialised as just a headache when, in reality, it can be a debilitating, chronic condition that can destroy lives' said Simon Evans, Chief Executive, Migraine Action. 'The effects can last for hours – even days in many cases. An option that can prevent migraine and that is well tolerated is therefore sorely needed and we hope that this marks the start of real change in how this condition is treated and perceived.'

Professor Peter Goadsby is a National Institute for Health Research (NIHR) Senior Investigator.

Notes to editors

For further media information please contact Jack Stonebridge, Senior Press Officer, Institute of Psychiatry, Psychology & Neuroscience, King’s College London on jack.stonebridge@kcl.ac.uk or 020 7848 5377.

Paper reference: Goadsby, P et al (2017) A Controlled Trial of Erenumab for Episodic Migraine New England Journal of Medicine (NEJM).

News Highlights:

News Highlights...RSS FeedAtom Feed

Complications at birth associated with lasting chemical changes in the brain

Complications at birth associated with lasting chemical changes in the brain

Description
New King's College London research, published today in eLife, shows that adults born prematurely - who also suffered small brain injuries around the time of birth - have lower levels of dopamine in the brain.
Potential for machine learning to predict unknown adverse drug reactions

Potential for machine learning to predict unknown adverse drug reactions

Description
Research funded by the NIHR Maudsley Biomedical Research Centre, published in Scientific Reports today (Monday 27 November) shows that machine learning has the potential to predict unknown adverse drug reactions.
Scientists reveal new avenue for drug treatment in neuropathic pain

Scientists reveal new avenue for drug treatment in neuropathic pain

Description
New research from King's College London has revealed a previously undiscovered mechanism of cellular communication, between neurons and immune cells, in neuropathic pain.
Sitemap Site help Terms and conditions  Privacy policy  Accessibility  Modern slavery statement  Contact us

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454