Paul Janssen Lecture
The Paul Janssen Lecture has been a regular feature of the academic calendar at the Institute of Psychiatry, Psychology & Neuroscience for nearly 20 years.
Lecturers are chosen on the basis of their global eminence in the field of neuroscience with a focus on schizophrenia. The annual lecture is named in honour of Belgian pharmacologist Paul Janssen (1926–2003) noted for discovering various drugs important to psychiatry, such as haloperidol, and who founded Janssen – the pharmaceutical company which sponsors the event.
This is a free event. Places are allocated on a first come first served basis and booking is essential.
20th Paul Janssen Lecuture 2020
19th Paul Janssen Lecture 2018
Wednesday 22nd January 2020 at 17:30 | Wolfson Lecture Theatre IoPPN Main Building
Precision Psychiatry: paradigm shift in neuroscience and clinical care or empty hope?
Speaker: Professor Nikolaos Koutsouleris
Chair: Professor Philip McGuire
Vote of Thanks: Paolo Fusar-Poli
Professor Nikolaos Koutsouleris Biography
Professor Nikolaos Koutsouleris is the Coordinator of the EU-FP7 funded project PRONIA ("Personalised Prognostic Tools for Early Psychosis Management"; www.pronia.eu). He serves as consultant and Head of the Centre for Adolecent Psychiatry and Transitional Youth Mental Health and the Section for Neurodiagnostic Applications in Psychiatry at the Department of Psychiatry, Ludwig-Maximilian-University, Munich (LMU). Dr. Koutsouleris studied medicine at LMU between 1996 and 2003 as scholar of the German National Academic Foundation. He took his first medical & academic appointment in 2004 at the Department of Psychiatry and Psychotherapy, where he finished his doctorate thesis in 2005. Since 2008, Prof Koutsouleris has advanced the use of multivariate pattern recognition methods for the identification and validation of diagnostic and prognostic prediction models in at-risk and early stages of affective and non-affective psychoses. His work was awarded with several national and international prizes and led so far to over 80 peer-reviewed, highly cited papers. In addition, he strived to make robust machine-learning methods available to researchers in the clinical neurosciences in order to improve the methodological rigour of this new research direction based on the proper use of validation and model sharing approaches. These efforts have the lead to the publication of the open-source NeuroMiner machine learning platform available at www.pronia.eu/neurominer.
20th Paul Janssen Lecture is available on King's College YouTube Channel: Precision Psychiatry: paradigm shift in neuroscience and clinical care or empty hope?
18th Paul Janssen Lecture 2018
19th Paul Janssen Lecture 2018
Wednesday 5th December 2018 at 18:00 | Wolfson Lecture Theatre IoPPN Main Building
Epigenomic pathways to schizophrenia: genetics, environment and development
Speaker: Professor Jonathan Mill
Chair and Vote of Thanks: Professor Philip McGuire
Professor Jonathan Mill's Biography
Jonathan is Professor of Epigenetics at the University of Exeter Medical School and also heads the Psychiatric Epigenetics group at the Institute of Psychiatry, King's College London. He graduated with a degree in Human Sciences from Oxford University, where he took a particular interest in cannibalism, before undertaking his PhD in psychiatric genetics at the Institute of Psychiatry. After spending three years as a Canadian Institutes of Health Research (CIHR) postdoctoral fellow at the University of Toronto, he returned to the Institute of Psychiatry to establish the Psychiatric Epigenetics group in the MRC Social, Genetic and Developmental Psychiatry Centre. He was appointed as Professor of Epigenetics at UEMS in September 2012.
The research in Jonathan's group focuses primarily on the role of epigenetic processes in mediating the interplay between genes and the environment in common, complex disease phenotypes. Although their work is particularly focussed on neuropsychiatric phenotypes, their research spans the spectrum of biomedical disease phenotypes. Additional information can be found at www.epigenomicslab.com.
Jonathan's group takes an integrated genetic-epigenetic approach to complex disease phenotypes, and has considerable experience in high-throughput epigenomic profiling. The recently took the lead on the first systematic genome-wide scan for DNA methylation changes associated with schizophrenia and bipolar disorder, and are currently funded to perform methylomic studies of schizophrenia, bipolar disorder, autism, alcoholism, and Alzheimer’s disorder. Their research aims to understand the role of functional epigenetic variation in mediating the interplay between genes and the environment in disease.
19th Paul Janssen Lecture is available on King's College YouTube Channel: Epigenomic pathways to schizophrenia: genetics, environment and development
17th Paul Janssen Lecture 2016
Thursday 25th January 2018 at 6.00pm | Wolfson Lecture Theatre IoPPN Main Building
"Trajectories of brain change in psychosis: ‘risk’ or ‘resilience’?"
Speaker: Professor Christos Pantelis
Chair: Professor Anthony David
Vote of Thanks: Professor Ian Everall
Professor Christos Pantelis’ Biography
Professor Christos Pantelis is an NHMRC Senior Principal Research Fellow, Foundation Professor of Neuropsychiatry and Scientific Director of the Melbourne Neuropsychiatry Centre at The University of Melbourne and Melbourne Health. He holds an Honorary Professorial Fellow position at the Florey Institute for Neuroscience & Mental Health and heads the Adult Mental Health Rehabilitation Unit at Sunshine Hospital. He is an Honorary Adjunct Professor in the Centre for Neural Engineering (CfNE), Department of Electrical and Electronic Engineering at University of Melbourne.
He leads a team of over 60 clinical and research scientists and students that have been undertaking neuroimaging and neuropsychological work in schizophrenia and psychosis, and other psychiatric and neurodegenerative disorders since 1993 in Australia. His work has focused on brain structural and functional changes during the transition to psychosis. His group was the first to describe progressive brain structural changes at psychosis onset, with a seminal paper published in The Lancet in 2003.
Professor Christos Pantelis has established a unique resource of over 5,000 multimodal brain scans in patients with schizophrenia and other neuropsychiatric disorders, including longitudinal imaging. Recent work focuses on early developmental disorders, including children with schizotypal features and autism.
He was named in the Thomson Reuters list of “The World’s Most Influential Scientific Minds” for 2014, 2015 and 2016, representing the top 1% of most highly cited scientists in his field. He is on the Editorial Boards of national and international journals, including Associate Editor for Psychological Medicine.
18th Paul Janssen Lecture is available on King's College YouTube Channel: Trajectories of brain change in psychosis: ‘risk’ or ‘resilience’?
Wednesday 9th November 2016 at 6.30pm | Wolfson Lecture Theatre IoPPN Main Building
"Translating from animal models to human schizophrenia: insights into pathophysiology, treatment and prevention"
Speaker: Prof Anthony A. Grace
Chair: Prof Anthony David
Vote of Thanks: Prof Philip McGuire
Distinguished Professor of Neuroscience. Professor of Psychiatry and Psychology - Department of Neuroscience - University of Pittsburgh
Abstract: There is considerable evidence that schizophrenia involves a dysregulated dopamine system, potentially driven by over-activity in the hippocampus. Furthermore, multiple postmortem studies of schizophrenia brains show a substantial loss of a particular type of inhibitory neuron known as the parvalbumin GABAergic interneuron; loss of this neuron is thought to drive the hippocampal hyperactivity and dysrhythmic activity, leading to an over-responsive dopamine system. Our studies suggest that when the hippocampus is hyperactive and dysrhythmic, the dopamine system is hyper-responsive to stimuli, which can underlie the resultant hallucinations and delusions. A major question is why there is interneuron loss in the hippocampus. Parvalbumin interneurons early in life are susceptible to damage due to stress. In a developmental disruption model of schizophrenia in the rat, we found that prepubertally these rats are hyper-responsive to stress, and furthermore relieving the stress early in life prevents the transition to “psychosis” in adulthood. This suggests that schizophrenia susceptibility may be due to heightened sensitivity to the deleterious effects of stress. Indeed, multiple stressors given during this sensitive period to normal rats can lead to the schizophrenia phenotype. Moreover, elimination of the ability of the medial prefrontal cortex to regulate stress makes normal rats hypersensitive to stressors that would not impact an intact rat. Therefore, controlling stress early in life in susceptible individuals may be an effective means to prevent transition to schizophrenia later in life.
Dr. Anthony A. Grace is a Distinguished Professor of Neuroscience and a Professor of Psychiatry and Psychology at the University of Pittsburgh in Pittsburgh, PA. He received his Ph.D. from Yale University School of Medicine with Dr. Benjamin S. Bunney and had postdoctoral training with Dr. Rodolfo Llinas in the Department of Physiology and Biophysics at New York University School of Medicine. Dr. Grace has been involved in translational research related to the dopamine system for over 30 years. His early work pioneered the mode of action of antipsychotic drugs, and the identification and characterization of dopamine-containing neurons. His current work involves novel treatments for schizophrenia and its prevention, the role of dopamine in anhedonia and affective disorders, and the mode of action of ketamine and novel antidepressant drugs.
16th Paul Janssen Lecture 2015
Thursday 5th of November 2015 at 5.30pm
The Paradoxes of Dopamine Dysfunction in Schizophrenia
Speaker: Professor Anissa Abi-Dargham
Professor of Psychiatry and Radiology at CUMC, Columbia University & New York State Psychiatric Institute
Chair: Prof Anthony David
Vote of Thanks: Dr Oliver Howes
Wolfson Lecture Theatre
Institute of Psychiatry, Psychology & Neuroscience
15th Paul Janssen Lecture 2014
Schizophrenia genetics: settling the score
10 December 2014, 17.30–18.30
Speaker: Professor Michael O’Donovan, MRC Centre for Psychiatric Genetics & Genomics
Chair: Professor Anthony David
Vote of Thanks: Professor Sir Robin Murray
Wolfson Lecture Theatre, Institute of Psychiatry, Psychology & Neuroscience, Denmark Hill, London
A reception will follow in Seminar Rooms 1 & 2 from 18.30
Professor Michael O'Donovan's Biography
Professor of Psychiatric Genetics Michael O’Donovan studied both Physiology and Medicine at Glasgow University, Psychiatry in Paisley (Scotland) and Cardiff (Wales) and genetics in Cardiff and Boston (USA).
Clinically, Michael specialises in diagnosis and management of schizophrenia and psychosis.
Michael has published over 300 scientific papers into molecular genetic studies of psychotic disorders, as well as a range of other disorders including ADHD and Alzheimer’s disease.
Michael leads a large international schizophrenia research consortium and is also the Academic Psychiatry Lead for the Royal College of Psychiatrists in Wales.
14th Paul Janssen Lecture 2013
Preventing schizophrenia: easier than you think?
Professor John McGrath, Queensland Brain Institute, University of Queensland, Australia
Chair: Professor Tony David
Vote of Thanks: Professor Sir Robin Murray.
A video of the event is available here
If you wish to download the lecture in MP3 format, right click the following link then "Save target as" Download Preventing Schizophrenia- easier than you think?
13th Paul Janssen Lecture 2012
Why can’t psychiatric genetics be more like neurology?
Professor John Hardy, Head of Department of Molecular Neuroscience, Institute of Neurology UCL
The event focused on psychiatric genetics and neurology, with Professor Tony David acting as chair and Vote of thanks provided by Professor Sir Robin Murray.
If you wish to download the lecture in MP3 format, right click the following link and "Save target as" Download Why can’t psychiatric genetics be more like neurology
12th Paul Janssen Lecture 2010
Adaptive regulation of cognitive control: neural mechanisms and implications for mental illness
Professor Jonathan D. Cohen, Eugene Higgins Professor & Director, Center for the Study of Brain, Mind & Behavior, Princeton University, New Jersey; & Professor of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania
Chair: Professor Tony David
11th Paul Janssen Lecture 2009
The simple truth about the genetic complexity of schizophrenia
Professor Daniel Weinberger, National Institute of Health in Bethesda, Maryland
Chair: Professor Tony David
Vote of thanks: Professor Philip McGuire
9th Paul Janssen Lecture 2007
What can genes tell us about the brain and schizophrenia
Professor Andreas Meyer-Lindenberg, Director, Central Institute of Mental Health, Mannheim & Medical Director, Department of Psychiatry
This Paul Janssen lecture is looking at the involvement of genes on schizophrenia and the brain. This lecture will look at the work to characterize the neural effects of risk genes for schizophrenia, in order to find out more about the illness and identify new treatment targets.
Dr. Meyer-Lindenberg studied medicine at Bonn (Germany) and Cornell University and did residencies in psychiatry and psychotherapy in Giessen (Germany) and in neurology in Bonn. He received his M.D. in 1991 and his Ph.D. (Habilitation) in 1999. He is board certified in psychiatry, psychotherapy and neurology. He also holds a Master's degree in pure and applied mathematics from the University of Hagen (Germany).
If you wish to download the lecture in MP3 format, right click the following link as "Save target as" Download What genes tell us about the brain and schizophrenia