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Job id: 088288. Salary: £37,332 - £42,099 per annum, including London Weighting Allowance.

Posted: 08 May 2024. Closing date: 22 May 2024.

Business unit: IoPPN. Department: Developmental Neurobiology.

Contact details: Dr Katie Long / Prof. Beatriz Rico. Katie.long@kcl.ac.uk / Beatriz.rico@kcl.ac.uk

Location: Guy's Campus. Category: Research.

Job description

Applications are invited for an enthusiastic Research Assistant to work within the MRC Centre for Neurodevelopmental Disorders, developing the human post-mortem tissue resource. This resource aims to expand and collect clinically phenotyped samples for use by the local and wider research community. 

As a member of the team, the post-holder will be working in close collaboration with a multidisciplinary team of researchers and clinical staff from both KCL and GSTT, alongside different project partners. They will provide logistical, technical and organisational support for the generation and maintenance of human clinical samples that adhere to both Guys and St Thomas (GSTT) NHS Trust governance and Human Tissue Act (HTA) guidelines. They will be responsible for both the scientific support of the tissue resource and the co-ordination of sample collection, data management and tissue processing and storage. The post-holder would also be expected to have an active role in existing research studies and in the development of new research. They will be highly motivated, approachable and able to proactively liaise with a variety of professional figures within both King’s College London and the Guy’s and St Thomas’ NHS Trust. 

Applicants should have a strong background in clinical and/or neuroscience research. Experience with human tissue work and HTA compliance are essential. Candidates should be motivated, a team-player and be able to work on their own initiative. The candidate will benefit from state-of-the-art research facilities and the intellectual environment and interactive culture of the Centre for Developmental Neurobiology, School of Biomedical Engineering and Imaging Sciences and St Thomas Hospital. 

This post will be offered on an a fixed-term contract for 24 months.

This is a full-time  post - 100% full time equivalent.

Key responsibilities

  • Day to day running of the human fetal and neonatal post-mortem brain tissue resource
  • Collect, prepare and store clinical / patient neurosurgery human samples
  • Assist with the generation, maintenance and review of Standard Operating Procedures, Risk Assessments, Ethics applications, Material Transfer Agreements and Laboratory Protocols
  • Assist in preparing requests for tissue from researchers both locally and internationally
  • Assist with sample preparation and processing, including frozen tissue.
  • Assist with experiments, microscopy imaging and analysis.
  • Maintain and provide detailed records of data generated and associated analysis and ensure compliance with Home Office, HTA and other regulatory requirements for record keeping

The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.

Skills, knowledge, and experience

Essential criteria

1.       Degree in Biological Sciences or related discipline

2.       NHS/Clinical and/or experience in a research laboratory

3.       Experience in rodent/primate sample (tissue and blood) collection, handling, preparation (fixed and fresh), shipment, storage and disposal.

4.       Experience in writing, maintaining and auditting Standard Operating Procedures and Risk Assessments

5.       Proficient in data entry, maintaining and retrieval from sample databases for example: FreezerPro, NHS clinical patient record databases (EDGE, EPR, CRIS, CPMS).

6.       Experience maintaining lab consumables and equipment such as fridge/freezers, T-Scans compliant with HTA

7.       Ability to trouble shoot laboratory problems

8.       Ability to work collaboratively

9.       Ability to manage multiple tasks concurrently

10.     Ability to work independently

Desirable criteria

1.       Experience in human cell and tissue culture

2.       Experience/knowledge of imaging modalities, such as clinical MRI, neuroimaging, widefield and confocal microscopy

3.       Experience in human sample (tissue and blood) collection, handling, preparation (fixed and fresh), shipment, storage and disposal, compliant with Ethics and HTA standards.

4.       Background in neuroscience

5.      Knowledge of human fetal and adult brain anatomy

This post is subject to a Occupational Health Clearance.