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Job id: 092226. Salary: £32,979 - £36,396 per annum, including London Weighting Allowance.

Posted: 10 July 2024. Closing date: 17 July 2024.

Business unit: Faculty of Life Sciences & Medicine. Department: Comprehensive Cancer Centre.

Contact details: Jodie Bellamy. Jodie.bellamy@kcl.ac.uk

Location: Guy's Campus. Category: Professional & Support Services.

About us

Dr Sheeba Irshad is a medical oncologist with an interest in understanding differences in immune surveillance mechanisms that may drive cancer disparities.   The team are part of a global team led by Prof Melissa Davis from Morehouse Medical School, Atlanta who have been awarded the CRUK Grand Challenge for their project entitled SAMBAI.   SAMBAI is taking a multi-level, interdisciplinary approach to build the SAMBAI Biobank and Data Repository for Cancer Equity Research, spanning diverse cohorts of African descent from regions of Africa, the UK and the US. This unprecedented resource will enable an integrated set of analyses to define the factors that influence disparate outcomes in these populations.   The team will focus on breast, pancreatic and prostate cancers – three cancer types that have a disproportionately higher rate of aggressive tumour grade and early onset in Black people – and aims to deliver a data repository with millions of data features per person for 40,000 people.  

About the role

We are seeking a Junior Research Technician to join Dr Sheeba Irshad’s laboratory within the Breast Immunology Group, based at the Innovation Hub, Guy’s Cancer Centre, KCL Guy’s Campus.

Inequities in cancer prevention, screening and treatment lead to disparities in cancer incidence and mortality and are major public-health challenges. Because the relative contributions of genetic/epigenetic, biological and social drivers of cancer aetiology remain unclear, approaches aimed at reducing inequities remain inadequate. A crucial step in reaching cancer equity is fully understanding all aspects underpinning disparities, from environment to intrinsic biology. Dr Sheeba Irshad is a medical oncologist with an interest in understanding differences in immune surveillance mechanisms that may drive cancer disparities.   The team are part of a global team led by Prof Melissa Davis from Morehouse Medical School, Atlanta who have been awarded the CRUK Grand Challenge for their project entitled SAMBAI.   SAMBAI is taking a multi-level, interdisciplinary approach to build the SAMBAI Biobank and Data Repository for Cancer Equity Research, spanning diverse cohorts of African descent from regions of Africa, the UK and the US. This unprecedented resource will enable an integrated set of analyses to define the factors that influence disparate outcomes in these populations.   The team will focus on breast, pancreatic and prostate cancers – three cancer types that have a disproportionately higher rate of aggressive tumour grade and early onset in Black people – and aims to deliver a data repository with millions of data features per person for 40,000 people. 

Dr Irshad’s research group will lead work package 4 investigating the immune surveillance mechanisms across black and white patients.  

The post holder will work under the direct supervision of Dr Paul Buckley, Postdoctoral Research Associate in Dr Irshad’s laboratory. In addition, the post-holder will work in collaboration with additional post-doctoral researchers, Senior and Junior Technicians, and clinical fellows within the group.

As a Research Technician , the post-holder will be required to provide technical support to the experimental work being undertaken in Dr Irshad’s laboratory. The candidate will be expected to take direct responsibility of specific research projects by providing original intellectual input, experimental design, implementation and optimization of new techniques, research project management, data analysis, presentation of results at internal meetings and to assist in the preparation of manuscripts of the experimental work.

The post holder will receive relevant supervision and training in specialised techniques and will meet with their line manager on a regular basis to review results and plan experiments. Equally, once established, the post-holder should be able to work independently without the requirement for day-to-day supervision and is encouraged to contribute to the design of experiments. 

This is a full time post (35 Hours per week), and you will be offered an a fixed term contract until 06/03/26.

About you

To be successful in this role, we are looking for candidates to have the following skills and experience:

Essential criteria

1.      BSC (Hons) degree or equivalent in a relevant subject

2.      Expertise in immune phenotyping by flow cytometry

3.      Expertise in spatial phenotyping multiplexed imaging platforms.

4.      Proven experience of preparing scientific figures and presenting scientific work

5.      Proven ability to work independently, to design, conduct, optimise and analyse experiments, often implementing novel techniques.  

Desirable criteria

1.      MSc awarded (or near completion) in a relevant subject

Downloading a copy of our Job Description

Full details of the role and the skills, knowledge and experience required can be found in the Job Description document, provided at the bottom of the next page after you click “Apply Now”. This document will provide information of what criteria will be assessed at each stage of the recruitment process.

Further information.

We pride ourselves on being inclusive and welcoming. We embrace diversity and want everyone to feel that they belong and are connected to others in our community.

We are committed to working with our staff and unions on these and other issues, to continue to support our people and to develop a diverse and inclusive culture at King's.

We ask all candidates to submit a copy of their CV, and a supporting statement, detailing how they meet the essential criteria listed in the advert. If we receive a strong field of candidates, we may use the desirable criteria to choose our final shortlist, so please include your evidence against these where possible.

To find out how our managers will review your application, please take a look at our ‘How we Recruit’ pages.

We are not able to offer sponsorship for candidates who do not currently possess the right to work in the UK.

This post is subject to an Occupational Health clearance.