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Job id: 092346. Salary: £43,205 - £46,732 per annum, including London Weighting Allowance.

Posted: 09 July 2024. Closing date: 17 July 2024.

Business unit: Faculty of Life Sciences & Medicine. Department: Department of Infectious Diseases.

Contact details: Michael Malim.

Location: Guy's Campus. Category: Research.


About Us

Animal cells express genes and pathways that naturally inhibit the replication of viruses.  The balance between these innate/intrinsic inhibitors and the many factors that promote replication establishes the tempo of virus infection and, ultimately, contributes to disease outcome.  Research in Prof Malim’s lab primarily addresses interactions between human cells, genes & proteins and pathogenic human viruses, including human immunodeficiency virus (HIV), influenza A virus (IAV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – all with a view to understanding the fundamental principles that underpin virus infection, replication, transmission, zoonosis and pathogenesis.  Projects employ a multi-disciplinary blend of experimental approaches that draws upon molecular-genetic, cultured cell, biochemical, structural, bioinformatic and cohort-based methodologies.

About the role

The Malim lab, in collaboration with Luis Apolonia’s team, are exploiting natural genetic variation between humans to define differences in susceptibility to HIV-1 infection and replication as a pathway to defining cell-determined regulators of the HIV-1 life cycle. The work is based on prior screening of panels of human induced pluripotent stem cell lines (iPSCs) for phenotypic differences in infection, followed by the identification of correlations between cell lines that display extreme phenotypes and distinctive features of their transcriptomes and genome sequences. The two iPSC panels have been tested: one, a subset of the UK-based HipSci resource; and, two, an in-house panel of novel lines generated from participants in the US-based MACS study. Candidate genes and pathways identified through bio-informatic and statistical methods will be functionally interrogated for their impact on HIV-1 replication through over-expression and silencing methods using cultured cell models of infection, including macrophages. Subsequent functional studies using an established suite of virological techniques will define the specific roles of individual genes in controlling virus infection.

The role holder will join a vibrant team of post-doctoral fellows and research associates, post-graduate students and undergraduate/ masters-level students to undertake discovery-inspired and internationally-distinctive research on the interplay between HIV-1 replication and the infected host cell from a genome-wide perspective.  The role requires skills in molecular biology, cell biology, molecular genetics and bioinformatics/ statistics.  The appointee will be expected to display academic and technical leadership and innovation, culminating in research publications, presentations at international meetings/ conferences, and applications for extra-mural research funding.

This is a full-time post (35 hours per week), and you will be offered  a fixed term contract until 31 July 2026.

About You

To be successful in this role, we are looking for candidates to have the following skills and experience:

Essential criteria

  1. PhD in relevant subject area*
  2. Experience in culturing iPSCs, HIV-1 infection studies, transcriptomics, bioinformatics/ statistics and molecular biology
  3. Evidence of 4* research outputs or potential
  4. Track record of participating actively in the planning, execution and interpretation of research projects
  5. Ability to communicate effectively with clinical, academic and managerial colleagues; at King’s and externally
  6. Ability to self-motivate and work flexible hours
  7. Ability to work co-operatively and collegially as a team member

*Please note that this is a PhD level role but candidates who have submitted their thesis and are awaiting award of their PhDs will be considered. In these circumstances the appointment will be made at Grade 5, spine point 30 with the title of Research Assistant. Upon confirmation of the award of the PhD, the job title will become Research Associate and the salary will increase to Grade 6.

Desirable criteria

  1. Planning and preparation of applications for extra-mural research funding
  2. Peer-reviewed publications in high quality virology or more generalist journals, and/or evidence of oral/poster presentations at international scientific conferences
  3. Experience of working in a CL3 laboratory

Downloading a copy of our Job Description

Full details of the role and the skills, knowledge and experience required can be found in the Job Description document, provided at the bottom of the next page after you click “Apply Now”. This document will provide information of what criteria will be assessed at each stage of the recruitment process.

Further Information

We pride ourselves on being inclusive and welcoming. We embrace diversity and want everyone to feel that they belong and are connected to others in our community.

We are committed to working with our staff and unions on these and other issues, to continue to support our people and to develop a diverse and inclusive culture at King's. We ask all candidates to submit a copy of their CV, and a supporting statement, detailing how they meet the essential criteria listed in the advert. If we receive a strong field of candidates, we may use the desirable criteria to choose our final shortlist, so please include your evidence against these where possible.

To find out how our managers will review your application, please take a look at our ‘How we Recruit’ pages.

Interviews are due to be held soon after advert closes.

We are able to offer sponsorship for candidates who do not currently possess the right to work in the UK.

This post is subject to Occupational Health clearances.