King's College London

About us:

The King’s College London Gene Therapy Vector Facility (GTVF) provides comprehensive GMP-grade viral vector manufacturing services. This includes Lentiviral Vector (LV), Retroviral Vector (RV) and Adeno-Associated Viral Vector (AAV) production for early-phase clinical trials, alongside substantial programmes in process innovation, knowledge transfer and training to address critical skills shortages. 

In partnership with the Network of Innovation Hubs, our vision is to ensure that the UK capitalises on its outstanding academic medical research to deliver novel gene therapies to patients, providing transformative treatments for currently intractable conditions, and generating a vibrant economic landscape. 

The GTVF is run by a large, industry-leading team of >50 people who have extensive experience in delivering end-to-end viral vector manufacture for both academic and commercial clients, with a focus on early-stage clinical trials. 

About the role:

The candidate will be part of a wider group of dedicated Development, Production Scientists and Quality Assurance staff and will be accountable for managing a team delivering demand planning and procurement of consumables and key materials for GMP manufacturing.  

The role will be responsible for ensuring that materials required for manufacturing are delivered, approved and ready at the point of use as required, in addition to overseeing logistics of shipping samples and products to various sites as requested by operation and client. The candidate will also be responsible for receiving tissues and samples for further processing to produce Advanced Therapy Medicinal Products (ATMPs).  The candidate will also support and provide cover as necessary for environmental monitoring activities within the GMP cleanrooms.

Training will be provided in all aspects of Good Manufacturing Practice in order to comply with regulatory requirements.

This position provides an opportunity to continue to build and develop experience of supply chain discipline in forecasting, procurement and material management to ensure manufacturing of these specialised products are delivered on time to the appropriate quality standards.

The GMP facilities are currently undergoing growth and development across multiple sites. This offers an exciting opportunity to contribute to the expansion of the supply chain team, supporting an increase in demand and supply of critical manufacturing consumables, reagents and environmental monitoring activities.

The Supply Chain Manager will be responsible to the Head of Supply Chain and Facility Management, CGT-K.

This is a full time and you will be offered an indefinite  contract.

About you:

To be successful in this role, we are looking for candidates to have the following skills and experience:

Essential criteria

1. Significant experience and knowledge of working to Good Manufacturing Practice (GMP) standards
2. Extensive experience in material management including demand management, procuring, supplier management and stock monitoring, relationship building, development of SLAs
3. Significant experience using Quality Management system for complaint management, managing change, deviations and writing specifications
4. Experience managing a team
5. Significant experience of establishing and auditing new suppliers
6. Significant experience of logistics and dispatch of samples and products, to 3rd party/ client sites, ensuring requirements for shipment are followed for quality of the sample/ product
7. Significant experience in developing and building supplier relationships to ensure reliable supply of stock and deliver effective cost negotiation
8. Perform supplier audits, Management of material risk assessments, material specifications, control strategy

Desirable criteria

1. Experience in performing running an EM function or performing environmental monitoring and interpreting results.  Knowledge of typical bacterial and fungal flora found in cleanroom environments.
2. Experience in working a MHRA  / FDA / EMA licensed environment.