King's College London

THE VACANCY IS OPEN TO INTERNAL CANDIDATES ONLY

About Us

We are seeking an enthusiastic, proactive, and collaborative biologist to join Dr Yan’s Group in the School of Biomedical Engineering & Imaging Sciences, King’s College London. You will join a dynamic radiochemistry and biology Team with access to both cutting-edge instrumentation for preclinical molecular imaging. Together, we are developing next-generation whole-body imaging tools for cancer diagnosis, monitoring of therapeutic response, and detection of drug resistance.  

About The Role

The successful candidate will evaluate novel PET tracers to the detection of CAR T-cell’s biodistribution and behaviour in preclinical mouse cancer models. The project involves the generation of cancer targeting CAR T-cells, in vitro biological evaluation of CAR T-cell specific radiotracers, establishing tumour xenograft models, and PET imaging of CAR T-cells in tumour xenograft models with newly developed PET tracers. The ultimate goal is to develop a generic long-term CAR T-cell PET imaging strategy to enable clinicians to determine the real-time in vivo biodistribution of the CAR T-cells allowing prediction of therapeutic efficacy and potential off-target toxicity of therapeutic cells at earlier stages of their development.  

We expect the successful candidate to hold a MRes degree and research experience in CAR T-cell biology and have a strong track record of research achievements. Experience in handling of radioactivity is necessary.  

This is a full-time post (35 Hours per week), and you will be offered  a fixed term contract for 12 months.

About You

To be successful in this role, we are looking for candidates to have the following skills and experience: 

Essential criteria

1. MRes awarded in CAR T-cell biology or similar,
2. Experience in collecting blood from healthy human volunteers, T-cell isolation, CAR T-cell engineering,
3. Advanced skills to independently design and implement complex experiments and in analysis of complex research data;
4. Experience of safe handling of radioisotopes
5. Proven experience of manuscript preparation and presenting scientific research in the form of posters and oral presentations;
6. Excellent organisational skills, ability to act on personal initiative and take responsibility for own work, ensuring projects are completed, working to deadlines;
7. Excellent communication skills and work effectively in a multidisciplinary research environment.

Desirable criteria

1. Experience in small animal PET/SPECT imaging

Downloading a copy of our Job Description

Full details of the role and the skills, knowledge and experience required can be found in the Job Description document, provided at the bottom of the next page after you click “Apply Now”. This document will provide information of what criteria will be assessed at each stage of the recruitment process.

Further Information

We pride ourselves on being inclusive and welcoming. We embrace diversity and want everyone to feel that they belong and are connected to others in our community. 

We are committed to working with our staff and unions on these and other issues, to continue to support our people and to develop a diverse and inclusive culture at King's. We ask all candidates to submit a copy of their CV, and a supporting statement, detailing how they meet the essential criteria listed in the advert. If we receive a strong field of candidates, we may use the desirable criteria to choose our final shortlist, so please include your evidence against these where possible.

To find out how our managers will review your application, please take a look at our ‘How we Recruit’ pages.

This post is subject to Occupational Health clearances.