Location: Lecture Theatre 2, New Hunt's House, Guy's Campus
A novel way to analyse blood pressure signals for the earlier detection of disease
Speaker: Dr Manasi Nandi, Lecturer in Integrative Pharmacology
Summary: Physiological waveform data, such as blood pressure and ECG, are routinely sampled between 100-1000Hz in preclinical research and in hospital patients. However, much of the data is disregarded, such that the detail contained within the shape of the waveform is usually ignored and focus tends to reside in only reporting segments of the waveform, such as minimum (diastolic pressure), maximum (systolic pressure) and heart rate values.
We have developed a novel mathematical method to quantify previously undetectable changes in the cardiovascular system by working in collaboration with a mathematician (Dr Philip Aston – University of Surrey). It is known that variation in the contours and shape of blood pressure waveform relates to changes in cardiac contraction and vascular function. We believe this unique approach to quantify waveform shape, can tell us more about subtle changes in body systems before they are evident using standard methods.
In particular, we are interested in ascertaining whether this approach can provide earlier evidence that a patient is about to deteriorate before they actually ‘crash’, facilitating more timely diagnosis and disease management. In the setting of intensive care, this could be lifesaving.
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