Breast Cancer Biology Group
The Breast Cancer Biology Group is committed to translational research. It studies the molecular and phenotypic changes that occur in breast cancer with the aim of translating the findings into clinical applications.
The laboratory has a particular focus on two molecules, MUC1 and PLU-1/JARID1B, both of which were discovered by the laboratory.
The studies on MUC1 have led to investigations into changes in glycosylation that occur in breast cancer. This field has greatly influenced the immunology studies, which include exploiting the change in glycosylation of MUC1 to target T cells expressing chimeric antigen receptors.
PLU-1/JARID1B is a histone demethylase that is expressed in breast cancers and the developing mammary gland while expression in other normal tissues is limited to the testis. These studies centre around its function in normal mammary gland development and in breast cancer, as well as exploring its potential as a therapeutic target.