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Research Groups

Cancer Evolutionary Genomics

Academic staff

Dr Francesca Ciccarelli
Reader in Bioinformatics and Genomics

Email: francesca.ciccarelli@kcl.ac.uk

Matteo Cereda
Post Doctoral Fellow (computational)
Email:
matteo.cereda@kcl.ac.uk

Gennaro Gambardella
Post Doctoral Fellow (computational)
Email:
gennaro.gambardella@kcl.ac.uk

Giovanni Dall’Olio
Post Doctoral Fellow (computational)
Email:
giovanni.dallolio@kcl.ac.uk

Lorena Benedetti
Post Doctoral Fellow (wet lab)
Email:
lorena.benedetti@kcl.ac.uk

Shruti Sinha
PhD Student
Email:
shruti.sinha@kcl.ac.uk

Omer An
PhD Student
Email:
omer.an@kcl.ac.uk

 

About the group

Our group is interested in studying the role of genomic instability – that is the dynamic acquisition of DNA modifications – in the onset and progression of human cancer.

We use both experimental and in silico approaches to produce and analyse cancer genomics data in order to rebuild the evolution of tumors. For example, we discovered that healthy cells of cancer patients with mismatch repair deficiency are constitutively unstable, thus suggesting that they are predisposed to acquire the second hit (De Grassi et al, PLoS Biol, 2010).

We are also interested in studying the properties of cancer genes to identify novel therapeutic targets. We assessed that cancer-promoting genes have evolutionary and systems-level properties that distinguish them from other human genes (Rambaldi et al, Trends in Genet, 2008; D’Antonio & Ciccarelli PLoS Comp Biol, 2011). This knowledge can be used to identify novel cancer-driver genes (D’Antonio & Ciccarelli Genome Biol, 2013) and to identify negative genetic partners of cancer genes (D’Antonio et al Cell Reports, 2013).

 

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