Prof Stephen Devereux
Professor in Lymphoma Biology
Tel: +44 (0)20 3299 4289
The main focus of the lymphoma biology team is to understand how interactions between malignant and non-malignant cells in the tumour microenvironment (TME) promote acquisition of cancer hallmark capabilities necessary for tumour growth and progression (survival, proliferation and immune privilege).
Research to date has demonstrated that tumour cells drive the construction of their own pro-lymphoma niche by regulating the recruitment, activation status and persistence of stromal and immune cells. Current work aims to further define the molecular mechanisms of these interactions so that novel therapies may be devised including harnessing immune cells to treat lymphomas and chronic lymphocytic leukaemia (CLL).
Figure: The lymphoma TME
controls tumour survival, proliferation and immune privilege