Dr Stephen Devereux
Professor in Lymphoma Biology
Tel: +44 (0)20 3299 4289
The main focus of the lymphoma biology team is to understand how interactions between malignant and non-malignant cells in the tumour microenvironment might influence disease progression. Current work concentrates on chronic lymphocytic leukaemia, the commonest haematological malignancy in the UK.
We have shown that interactions involving activated T cells and microvascular endothelial cells within the lymph node microenvironment are important factors in promoting disease progression and influence the expression of prognostic markers such as CD38. Current work aims to further define the molecular mechanisms of these interactions so that novel therapies may be devised.
Figure 1. CLL lymph node section showing relationship between proliferating tumour (red+blue), microvasculature (white) and T cells (green).
- A phenotypic and functional analysis of the T cell component of the tumour microenvironment in CLL.
- Characterisation of the mechanism underlying the anti-apoptotic effect of microvascular endothelial cells in CLL.
- The role of CD38 in tissue invasion in CLL.
- A “phenolog” approach for identifying gene abnormalities in chronic lymphocytic leukaemia.