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BHF Centre of Research Excellence

Selected Publications

2018 I 2017 I 2016 I 2015 I 20142013 I 2012 I 2011 I 2010 I 2009 I 2008

2018

  • Burr S, Caldwell A, Chong M, Beretta M, Metcalf S, Hancock M, Arno M, Balu S, Kropf VL, Mistry RK, Shah AM, Mann GE, Brewer AC. Oxygen gradients can determine epigenetic asymmetry and cellular differentiation via differential regulation of Tet activity in embryonic stem cells. Nucleic Acids Res. 2018;46:1210-1226
  • Engel LC, Landmesser U, Gigengack K, Wurster T, Manes C, Girke G, Jaguszewski M, Skurk C, Leistner DM, Lauten A, Schuster A, Hamm B, Botnar RM, Makowski MR, Bigalke B. Novel Approach for In Vivo Detection of Vulnerable Coronary Plaques using Molecular 3-T CMR Imaging with an Albumin-Binding Probe. JACC Cardiovasc Imaging. 2018;pii: S1936-878X(17)31152-X
  • Frudd K, Burgoyne T, Burgoyne JR. Oxidation of Atg3 and Atg7 mediates inhibition of autophagy. Nat Commun. 2018;9:95
  • Hervera A, De Virgiliis F, Palmisano I, Zhou L, Tantardini E, Kong G, Hutson T, Danzi MC, Perry RB, Santos CXC, Del Río JA, Carroll T, Lemmon V, Kapustin AN, Fleck R, Bixby JL, Shah AM, Fainzilber M, Di Giovanni S. NOX-dependent reactive oxygen species are essential regulators of axonal regeneration. Nature Cell Biol. 2018; 20:307-319
  • Jain T, Nikolopoulou EA, Xu Q, Qu A. Hypoxia inducible factor as a therapeutic target for atherosclerosis. Pharmacol. Ther. 2018;183:22-33
  • Mayr M, Gerszten R, Kiechl S. Cardiovascular Risk Beyond Low-Density Lipoprotein Cholesterol. J Am Coll Cardiol, 2018;71(6):633-635
  • O’Gallagher K, Khan F, Omar SA, Kalra S, Danson E, Cabaco AR, Martin K, Melikian N, Shah AM, Webb AJ. Inorganic nitrite selectively dilates epicardial coronary arteries. J Am Coll Cardiol. 2018; 71:363-364
  • Suna G, Wojakowski W, Lynch M, Barallobre-Barreiro J, Yin X, Mayr U, Baig F, Lu R, Fava M, Hayward R, Molenaar C, White SJ, Roleder T, Milewski KP, Gasior P, Buszman PP, Buszman P, Jahangiri M, Shanahan CM, Hill J, Mayr M. Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries. Circulation. 2018;137(2):166-183
  • Thakore P, Brain SD, Beech DJ. Correspondence: Challenging a proposed role for TRPC5 in aortic baroreceptor pressure-sensing. Nat Commun. 2018;9:1245.
  • Wolhuter K, Whitwell HJ, Switzer CH, Burgoyne JR, Timms JF, Eaton P. Evidence against Stable Protein S-Nitrosylation as a Widespread Mechanism of Post-translational Regulation. Mol Cell. 2018;69:438-450

2017

  • Asrress KN, Williams R, Lockie T, Khawaja MZ, de Silva K, Lumley M, Patterson T, Arri S, Ihsan S, Ellis H, Guilcher A, Clapp B, Chowienczyk PJ, Plein S, Perera D, Marber MS & Redwood SR. Physiology of Angina and its Alleviation with Nitroglycerine – Insights from Invasive Catheter Laboratory Measurements During Exercise. Circulation. 2017;136(1):24-34
  • Aubdool AA, Thakore P, Argunhan F, Smillie S-J, Schnelle M, Srivastava S, Alawi KM, Wilde E, Mitchell J, Farrell-Dillon K, Richards DA, Maltese G, Siow RC, Nandi M, Clark JE, Shah AM, Sams A, Brain SD. A novel α-calcitonin gene-related peptide analogue protects against end-organ damage in experimental hypertension, cardiac hypertrophy and heart failure. Circulation. 2017;136:367-383
  • Banerji CRS, Panamarova M, Hebaishi H, White RB, Relaix F, Severini S, Zammit PS. PAX7 target genes are globally repressed in FSHD skeletal muscle. Nat. Commun. 2017;8: 2152
  • Barwari T, Joshi A, Mayr M. Reply: The Complex miRNAs-p53 Signaling Network in Cardiovascular Disease. J Am Coll Cardiol. 2017;69(16):2100
  • Beedle, A. E., Mora, M., Lynham, S., Stirnemann, G., Garcia-Manyes, S. Tailoring protein nanomechanics with chemical reactivity. Nature Communications. 2017;8:15658.
  • Elosegui-Artola A, Andreu I, Beedle AEM, Lezamiz A, Uroz M, Kosmalska AJ, Oria R, Kechagia JZ, Rico-Lastres P, Le Roux AL, Shanahan CM, Trepat X, Navajas D, Garcia-Manyes S, Roca-Cusachs P. Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores. Cell. 2017;171(6):1397-1410.e14
  • El-Sayed T, Patel AS, Cho JS, Kelly J, Ludwinski F, Saha P, Lyons O, Smith A, Modarai B. Radiation Induced DNA Damage in Operators Performing Endovascular Aortic Repair. Circulation. 2017; 136:2406-2416
  • Floyd CN, Ferro A. Indications for anticoagulant and antiplatelet combined therapy. BMJ. 2017;359: j3782
  • Garcia-Manyes S, Beedle AEM. Steering chemical reactions with force. Nature Reviews Chemistry. 2017;1(11)
  • He L, Huang X, Kanisicak O, Li Y, Wang Y, Li Y, Pu W, Liu Q, Zhang H, Tian X, Zhao H, Liu X, Zhang S, Nie Y, Hu S, Miao X, Wang QD, Wang F, Chen T, Xu Q, Lui KO, Molkentin JD, Zhou B. Preexisting endothelial cells mediate cardiac neovascularization after injury. J. Clin. Invest. 2017;127:2968-2981
  • Kaier TE, Twerenbold R, Puelacher C, Marjot J, Imambaccus N, Boeddinghaus J, Nestelberger T, Badertscher P, Sabti Z, Giménez MR, Wildi K, Hillinger P, Grimm K, Loeffel S, Shrestha S, Widmer DF, Cupa J, Kozhuharov N, Miró Ò, Martín-Sánchez FJ, Morawiec B, Rentsch K, Lohrmann J, Kloos W, Osswald S, Reichlin T, Weber E, Marber M, MuellerC. Direct comparison of cardiac myosin-binding protein c with cardiac troponins for the early diagnosis of acute myocardial infarction. Circulation. 2017;136:1495-1508
  • Langley SR, Willeit K, Didangelos A, Matic LP, Skroblin P, Barallobre-Barreiro J, Lengquist M, Rungger G, Kapustin A, Kedenko L, Molenaar C, Lu R, Barwari T, Suna G, Yin X, Iglseder B, Paulweber B, Willeit P, Shalhoub J, Pasterkamp G, Davies AH, Monaco C, Hedin U, Shanahan CM, Willeit J, Kiechl S, Mayr M. Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques. J Clin Invest. 2017;127(4):1546-1560
  • Lyons O, Saha P, Seet C, Kuchta A, Arnold A, Grover S, Rashbrook V, Sabine A, Vizcay-Barrena G, Patel A, Ludwinski F, Padayachee S, Kume T, Kwak BR, Brice G, Mansour S, Ostergaard P, Mortimer P, Jeffery S, Brown N, Makinen T, Petrova TV, Modarai B, Smith A. Human venous valve disease caused by mutations in FOXC2 and GJC2. J Exp Med 2017;214: 2437-2452
  • Mills CE, Govoni V, Faconti L, Casagrande M, Morant S, Webb AJ, Cruickshank JK. Reducing arterial stiffness independently of blood pressure? The randomized, factorial ‘VaSera’ trial in people with or at risk of Type 2 Diabetes. Journal of the American College of Cardiology. 2017;70:1683-1684
  • Paschalaki KE, Zampetaki A, Baker JR, Birrell MA, Starke RD, Belvisi MG, Donnelly LE, Mayr M, Randi AM, Barnes PJ. Downregulation of MicroRNA-126 Augments DNA Damage Response in Cigarette Smokers and COPD Patients. Am J Respir Crit Care Med. 2017;197(5):665-668
  • Rahman H, Modi BN, Ellis H, Arri S, Perera D. A Lead to the Culprit. Circulation. 2017;136(9):877-879
  • Sag CM, Schnelle M, Zhang J, Murdoch CE, Kossmann S, Protti A, Santos CXC, Sawyer G, Zhang X, Mongue-Din H, Richards DA, Brewer AC, Prysyazhna O, Maier LS, Wenzel P, Eaton PJ, Shah AM. Distinct regulatory effects of myeloid cell and endothelial cell napdh oxidase 2 on blood pressure. Circulation. 2017;135:2163-2177
  • Sassi Y, Avramopoulos P, Ramanujam D, Grüter L, Werfel S, Giosele S, Brunner AD, Esfandyari D, Papadopoulou AS, De Strooper B, Hübner N, Kumarswamy R, Thum T, Yin X, Mayr M, Laggerbauer B, Engelhardt S. Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling. Nat Commun. 2017;8(1):1614
  • Viswambharan H, Yuldasheva NY, Sengupta A, Imrie H, Gage MC, Haywood NJ, Walker AM, Skromna A, Makova N, Galloway SL, Shah P, Sukumar P, Porter KE, Grant PJ, Shah AM, Santos CX, Li J, Beech DJ, Wheatcroft S, Cubbon RM, Kearney MT. Selective enhancement of insulin sensitivity in the endothelium in vivo reveals a novel proatherosclerotic signalling loop. Circ Res. 2017;120:784-798
  • Willeit K, Pechlaner R, Willeit P, Skroblin P, Paulweber B, Schernthaner C, Toell T, Egger G, Weger S, Oberhollenzer M, Kedenko L, Iglseder B, Bonora E, Schett G, Mayr M, Willeit J, Kiechl S. Association Between Vascular Cell Adhesion Molecule 1 and Atrial Fibrillation. JAMA Cardiol. 2017;2(5):516-523
  • Yu B, Kiechl S, Qi D, Wang X, Song Y, Weger S, Mayr A, Le Bras A, Karamariti E, Zhang Z, Del Barco Barrantes I, Niehrs C, Schett G, Hu Y, Wang W, Willeit J, Qu A, Xu Q. A Cytokine-like protein Dickopf-related protein 3 is atheroprotective. Circulation. 2017;136:1022-1036
  • Zampetaki A, Mayr M. Long Noncoding RNAs and Angiogenesis: Regulatory Information for Chromatin Remodeling. Circulation. 2017;136(1):80-82
  • Zhao G, Fu Y, Cai Z, Yu F, Gong Z, Dai R, Hu Y, Zeng L, Xu Q, Kong W. Unspliced XBP1 Confers VSMC Homeostasis and Prevents Aortic Aneurysm Formation via FoxO4 Interaction. Circ Res. 2017;121(12):1331-1345
  • Brangsch J, Reimann C, Collettini F, Buchert R, Botnar RM, Makowski MR.  Molecular Imaging of Abdominal Aortic Aneurysms. Trends in Molecular Medicine. 2017;23(2):150-64.
  • Cochrane A, Kelaini S, Tsifaki M, Bojdo J, Vila-Gonzalez M, Drehmer D, Caines R, Magee C, Eleftheriadou M, Hu Y, Grieve D, Stitt AW, Zeng L, Xu Q, Margariti A.  Quaking Is a Key Regulator of Endothelial Cell Differentiation, Neovascularization, and Angiogenesis. Stem Cells. 2017;35(4):952-66.
  • Donati F, Myerson S, Bissell MM, Smith NP, Neubauer S, Monaghan MJ, Nordsletten DA, Lamata P.  Beyond Bernoulli: Improving the Accuracy and Precision of Non-Invasive Estimation of Peak Pressure Drops. Circulation Cardiovascular imaging. 2017;10(1):e005207.
  • Gu H, Li Y, Fok H, Simpson J, Kentish JC, Shah AM, Chowienczyk PJ.  Reduced First-Phase Ejection Fraction and Sustained Myocardial Wall Stress in Hypertensive Patients With Diastolic Dysfunction: A Manifestation of Impaired Shortening Deactivation That Links Systolic to Diastolic Dysfunction and Preserves Systolic Ejection Fraction. Hypertension (Dallas, Tex : 1979). 2017;69(4):633-40.
  • Guentsch A, Beneke A, Swain L, Farhat K, Nagarajan S, Wielockx B, Raithatha K, Dudek J, Rehling P, Zieseniss A, Jatho A, Chong M, Santos CXC, Shah AM, Katschinski DM.  PHD2 Is a Regulator for Glycolytic Reprogramming in Macrophages. Molecular and Cellular Biology. 2017;37(1).
  • Hinkel R, Hoewe A, Renner S, Ng J, Lee S, Klett K, Kaczmarek V, Moretti A, Laugwitz K-L, Skroblin P, Mayr M, Milting H, Dendorfer A, Reichart B, Wolf E, Kupatt C.  Diabetes Mellitus–Induced Microvascular Destabilization in the Myocardium. Journal of the American College of Cardiology. 2017;69(2):131-43.
  • Jungbluth H, Ochala J, Treves S, Gautel M.  Current and future therapeutic approaches to the congenital myopathies. Seminars in Cell & Developmental Biology. 2017;64:191-200.
  • Kapustin AN, Schoppet M, Schurgers LJ, Reynolds JL, McNair R, Heiss A, Jahnen-Dechent W, Hackeng TM, Schlieper G, Harrison P, Shanahan CM.  Prothrombin Loading of Vascular Smooth Muscle Cell-Derived Exosomes Regulates Coagulation and Calcification. Arterioscler Thromb Vasc Biol. 2017;37(3):e22-e32.
  • Langley SR, Willeit K, Didangelos A, Matic LP, Skroblin P, Barallobre-Barreiro J, Lengquist M, Rungger G, Kapustin A, Kedenko L, Molenaar C, Lu R, Barwari T, Suna G, Yin X, Iglseder B, Paulweber B, Willeit P, Shalhoub J, Pasterkamp G, Davies AH, Monaco C, Hedin U, Shanahan CM, Willeit J, Kiechl S, Mayr M.  Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques. J Clin Invest. 2017;127(4):1546-60.
  • Li Y, Gu H, Fok H, Alastruey J, Chowienczyk P.  Forward and Backward Pressure Waveform Morphology in Hypertension: Novelty and Significance. Hypertension. 2017;69(2):375.
  • Nakada Y, Canseco DC, Thet S, Abdisalaam S, Asaithamby A, Santos CX, Shah AM, Zhang H, Faber JE, Kinter MT, Szweda LI, Xing C, Hu Z, Deberardinis RJ, Schiattarella G, Hill JA, Oz O, Lu Z, Zhang CC, Kimura W, Sadek HA.  Hypoxia induces heart regeneration in adult mice. Nature. 2017;541(7636):222-7.
  • Nasopoulou A, Shetty A, Lee J, Nordsletten D, Rinaldi CA, Lamata P, Niederer S.  Improved identifiability of myocardial material parameters by an energy-based cost function. Biomechanics and Modeling in Mechanobiology. 2017:1-18.
  • Nordio G, Henningsson M, Chiribiri A, Villa AD, Schneider T, Botnar RM.  3D myocardial T1 mapping using saturation recovery. J Magn Reson Imaging. 2017.
  • Pechlaner R, Tsimikas S, Yin X, Willeit P, Baig F, Santer P, Oberhollenzer F, Egger G, Witztum JL, Alexander VJ, Willeit J, Kiechl S, Mayr M.  Very-Low-Density Lipoprotein-Associated Apolipoproteins Predict Cardiovascular Events and Are Lowered by Inhibition of APOC-III. J Am Coll Cardiol. 2017;69(7):789-800.
  • Pernigo S, Fukuzawa A, Beedle AEM, Holt M, Round A, Pandini A, Garcia-Manyes S, Gautel M, Steiner RA.  Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection. Structure. 2017;25(1):107-20.
  • Shabeeh H, Khan S, Jiang B, Brett S, Melikian N, Casadei B, Chowienczyk PJ, Shah AM.  Blood Pressure in Healthy Humans Is Regulated by Neuronal NO Synthase. Hypertension. 2017.
  • Sunderland N, Skroblin P, Barwari T, Huntley RP, Lu R, Joshi A, Lovering RC, Mayr M.  MicroRNA Biomarkers and Platelet Reactivity. Circulation Research. 2017;120(2):418.
  • Willeit P, Skroblin P, Moschen AR, Yin X, Kaudewitz D, Zampetaki A, Barwari T, Whitehead M, Ramirez CM, Goedeke L, Rotllan N, Bonora E, Hughes AD, Santer P, Fernandez-Hernando C, Tilg H, Willeit J, Kiechl S, Mayr M.  Circulating MicroRNA-122 Is Associated With the Risk of New-Onset Metabolic Syndrome and Type 2 Diabetes. Diabetes. 2017;66(2):347-57.

2016

  • Alastruey J, Xiao N, Fok H, Schaeffter T, Figueroa CA.  On the impact of modelling assumptions in multi-scale, subject-specific models of aortic haemodynamics. Journal of The Royal Society Interface. 2016; 13(119).
  • Antonopoulos AS, Margaritis M, Verheule S, Recalde A, Sanna F, Herdman L, Psarros C, Nasrallah H, Coutinho P, Akoumianakis I, Brewer AC, Sayeed R, Krasopoulos G, Petrou M, Tarun A, Tousoulis D, Shah AM, Casadei B, Channon KM, Antoniades C.  Mutual Regulation of Epicardial Adipose Tissue and Myocardial Redox State by PPAR-gamma/Adiponectin Signalling. Circ Res. 2016; 118(5):842-55.
  • Bajwa A, Wesolowski R, Patel A, Saha P, Ludwinski F, Ikram M, Albayati M, Smith A, Nagel E, Modarai B.  Blood Oxygenation Level-Dependent CMR-Derived Measures in Critical Limb Ischemia and Changes With Revascularization. Journal of the American College of Cardiology. 2016;67(4):420-31.
  • Barallobre-Barreiro J, Gupta SK, Zoccarato A, Kitazume-Taneike R, Fava M, Yin X, Werner T, Hirt MN, Zampetaki A, Viviano A, Chong M, Bern M, Kourliouros A, Domenech N, Willeit P, Shah AM, Jahangiri M, Schaefer L, Fischer JW, Iozzo RV, Viner R, Thum T, Heineke J, Kichler A, Otsu K, Mayr M.  Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation. 2016;134(11):817-32.
  • Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X, Barwari T, Potier DN, Albadawi H, Jahangiri M, Porter KE, Watkins MT, Misra S, Stoughton J, Mayr M.  Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc Res. 2016;110(3):419-30.
  • Bauer A, Mylroie H, Thornton CC, Calay D, Birdsey GM, Kiprianos AP, Wilson GK, Soares MP, Yin X, Mayr M, Randi AM, Mason JC.  Identification of cyclins A1, E1 and vimentin as downstream targets of heme oxygenase-1 in vascular endothelial growth factor-mediated angiogenesis. Sci Rep. 2016;6:29417.
  • Beedle AEM, Lynham S, Garcia-Manyes S.  Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding. Nature Communications. 2016;7:12490.
  • Bennett PM, Ehler E, Wilson AJ.  Sarcoplasmic reticulum is an intermediary of mitochondrial and myofibrillar growth at the intercalated disc. Journal of Muscle Research and Cell Motility. 2016;37(3):55-69.
  • Brangsch J, Reimann C, Collettini F, Buchert R, Botnar RM, Makowski MR.  Molecular Imaging of Abdominal Aortic Aneurysms. Trends in Molecular Medicine. 2017;23(2):150-64.
  • Bromage DI, Jones DA, Rathod KS, Grout C, Iqbal MB, Lim P, Jain A, Kalra SS, Crake T, Astroulakis Z, Ozkor M, Rakhit RD, Knight CJ, Dalby MC, Malik IS, Mathur A, Redwood S, MacCarthy PA, Wragg A.  Outcome of 1051 Octogenarian Patients With ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention: Observational Cohort From the London Heart Attack Group. J Am Heart Assoc. 2016;5(6).
  • Chapple SJ, Keeley TP, Mastronicola D, Arno M, Vizcay-Barrena G, Fleck R, Siow RC, Mann GE.  Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels. Free Radic Biol Med. 2016;92:152-62.
  • Chen Z, Cabrera-Lozoya R, Relan J, Sohal M, Shetty A, Karim R, Delingette H, Gill J, Rhode K, Ayache N, Taggart P, Rinaldi CA, Sermesant M, Razavi R.  Biophysical Modeling Predicts Ventricular Tachycardia Inducibility and Circuit Morphology: A Combined Clinical Validation and Computer Modeling Approach. Journal of Cardiovascular Electrophysiology. 2016;27(7):851-60.
  • Chen Z, Hanson B, Sohal M, Sammut E, Jackson T, Child N, Claridge S, Behar J, Niederer S, Gill J, Carr-White G, Razavi R, Rinaldi CA, Taggart P.  Coupling of ventricular action potential duration and local strain patterns during reverse remodeling in responders and nonresponders to cardiac resynchronization therapy. Heart Rhythm. 2016;13(9):1898-904.
  • Cobb AM, Larrieu D, Warren DT, Liu Y, Srivastava S, Smith AJO, Bowater RP, Jackson SP, Shanahan CM.  Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient. Aging Cell. 2016;15(6):1039-50.
  • Cobb AM, Murray TV, Warren DT, Liu Y, Shanahan CM.  Disruption of PCNA-lamins A/C interactions by prelamin A induces DNA replication fork stalling. Nucleus. 2016;7(5):498-511.
  • Corrado C, Niederer SA.  A two-variable model robust to pacemaker behaviour for the dynamics of the cardiac action potential. Mathematical Biosciences. 2016;281:46-54.
  • Cubbon RM, Ruff N, Groves D, Eleuteri A, Denby C, Kearney L, Ali N, Walker AMN, Jamil H, Gierula J, Gale CP, Batin PD, Nolan J, Shah AM, Fox KAA, Sapsford RJ, Witte KK, Kearney MT.  Ambulatory heart rate range predicts mode-specific mortality and hospitalisation in chronic heart failure. Heart. 2016;102(3):223.
  • Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Buttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Muhlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F.  Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med. 2016;22(12):1428-38.
  • Fernandez-Caggiano M, Schroder E, Cho HJ, Burgoyne J, Barallobre-Barreiro J, Mayr M, Eaton P.  Oxidant-induced Interprotein Disulfide Formation in Cardiac Protein DJ-1 Occurs via an Interaction with Peroxiredoxin 2. J Biol Chem. 2016;291(19):10399-410.
  • Fu Y, Gao C, Liang Y, Wang M, Huang Y, Ma W, Li T, Jia Y, Yu F, Zhu W, Cui Q, Li Y, Xu Q, Wang X, Kong W.  Shift of Macrophage Phenotype Due to Cartilage Oligomeric Matrix Protein Deficiency Drives Atherosclerotic Calcification. Circ Res. 2016;119(2):261-76.
  • Fusi L, Brunello E, Yan Z, Irving M.  Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle. Nature Communications. 2016;7.
  • Hastings R, de Villiers C, Hooper C, Ormondroyd L, Pagnamenta A, Lise S, Salatino S, Knight SJL, Taylor JC, Thomson KL, Arnold L, Chatziefthimiou SD, Konarev PV, Wilmanns M, Ehler E, Ghisleni A, Gautel M, Blair E, Watkins H, Gehmlich K.  Combination of Whole Genome Sequencing, Linkage and Functional Studies Implicates a Missense Mutation in Titin as a Cause of Autosomal Dominant Cardiomyopathy with Features of Left Ventricular Non-Compaction. Circulation Cardiovascular genetics. 2016;9(5):426-35.
  • Khavandi K, Baylie RL, Sugden SA, Ahmed M, Csato V, Eaton P, Hill-Eubanks DC, Bonev AD, Nelson MT, Greenstein AS.  Pressure-induced oxidative activation of PKG enables vasoregulation by Ca2+ sparks and BK channels. Sci Signal. 2016;9(449):ra100.
  • Lumley M, Williams R, Asrress KN, Arri S, Briceno N, Ellis H, Rajani R, Siebes M, Piek JJ, Clapp B, Redwood SR, Marber MS, Chambers JB, Perera D.  Coronary Physiology During Exercise and Vasodilation in the Healthy Heart and in Severe Aortic Stenosis. J Am Coll Cardiol. 2016;68(7):688-97.
  • Luo Y, Feng J, Xu Q, Wang W, Wang X.  NSun2 Deficiency Protects Endothelium From Inflammation via mRNA Methylation of ICAM-1. Circ Res. 2016;118(6):944-56.
  • Nakayama H, Nishida K, Otsu K.  Macromolecular Degradation Systems and Cardiovascular Aging. Circulation Research. 2016;118(10):1577.
  • Prior KK, Wittig I, Leisegang MS, Groenendyk J, Weissmann N, Michalak M, Jansen-Durr P, Shah AM, Brandes RP.  The Endoplasmic Reticulum Chaperone Calnexin Is a NADPH Oxidase NOX4 Interacting Protein. J Biol Chem. 2016;291(13):7045-59.
  • Protti A, Mongue-Din H, Mylonas KJ, Sirker A, Sag CM, Swim MM, Maier L, Sawyer G, Dong X, Botnar R, Salisbury J, Gray GA, Shah AM.  Bone marrow transplantation modulates tissue macrophage phenotype and enhances cardiac recovery after subsequent acute myocardial infarction. J Mol Cell Cardiol. 2016;90:120-8.
  • Prysyazhna O, Burgoyne JR, Scotcher J, Grover S, Kass D, Eaton P.  Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Ialpha Oxidation. J Biol Chem. 2016;291(33):17427-36.
  • Rajgor D, Hanley JG, Shanahan CM.  Identification of novel nesprin-1 binding partners and cytoplasmic matrin-3 in processing bodies. Molecular Biology of the Cell. 2016;27(24):3894-902.
  • Swain L, Kesemeyer A, Meyer-Roxlau S, Vettel C, Zieseniss A, Guntsch A, Jatho A, Becker A, Nanadikar MS, Morgan B, Dennerlein S, Shah AM, El-Armouche A, Nikolaev VO, Katschinski DM.  Redox Imaging Using Cardiac Myocyte-Specific Transgenic Biosensor Mice. Circ Res. 2016;119(9):1004-16.
  • Trevelin SC, dos Santos CX, Ferreira RG, de Sá Lima L, Silva RL, Scavone C, Curi R, Alves-Filho JC, Cunha TM, Roxo-Júnior P, Cervi M-C, Laurindo FRM, Hothersall JS, Cobb AM, Zhang M, Ivetic A, Shah AM, Lopes LR, Cunha FQ.  Apocynin and Nox2 regulate NF-κB by modifying thioredoxin-1 redox-state. Scientific Reports. 2016;6:34581.
  • Ulrich V, Rotllan N, Araldi E, Luciano A, Skroblin P, Abonnenc M, Perrotta P, Yin X, Bauer A, Leslie KL, Zhang P, Aryal B, Montgomery RL, Thum T, Martin K, Suarez Y, Mayr M, Fernandez-Hernando C, Sessa WC.  Chronic miR-29 antagonism promotes favorable plaque remodeling in atherosclerotic mice. EMBO Mol Med. 2016;8(6):643-53.
  • Viswambharan H, Yuldasheva NY, Sengupta A, Imrie H, Gage MC, Haywood NJ, Walker AM, Skromna A, Makova N, Galloway SL, Shah P, Sukumar P, Porter KE, Grant PJ, Shah AM, Santos CX, Li J, Beech DJ, Wheatcroft S, Cubbon RM, Kearney MT.  Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signalling Loop. Circulation Research. 2016.
  • Willeit P, Skroblin P, Kiechl S, Fernandez-Hernando C, Mayr M.  Liver microRNAs: potential mediators and biomarkers for metabolic and cardiovascular disease? Eur Heart J. 2016;37(43):3260-6.
  • Zhang X, Kampourakis T, Yan Z, Sevrieva I, Irving M, Sun YB.  Distinct contributions of the thin and thick filaments to length-dependent activation in heart muscle. eLife. 2017;6.
  • Zhao Y, Li Y, Luo P, Gao Y, Yang J, Lao KH, Wang G, Cockerill G, Hu Y, Xu Q, Li T, Zeng L.  XBP1 splicing triggers miR-150 transfer from smooth muscle cells to endothelial cells via extracellular vesicles. Sci Rep. 2016;6:28627.

2015

  • Bettaieb A, Jiang JX, Sasaki Y, Chao T-I, Kiss Z, Chen X, Tian J, Katsuyama M, Yabe-Nishimura C, Xi Y, Szyndralewiez C, Schröder K, Shah A, Brandes RP, Haj FG, Török NJ.  Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice. Gastroenterology. 2015;149(2):468-80.e10.
  • Botnar RM, Kim WY.  Coronary MR Imaging: Moving From Lumenography to Plaque Assessment. JACC: Cardiovascular Imaging. 2015;8(10):1153-5.
  • Bratis K, Chiribiri A, Hussain T, Krasemann T, Henningsson M, Phinikaridou A, Mavrogeni S, Botnar R, Nagel E, Razavi R.  Abnormal Myocardial Perfusion in Kawasaki Disease Convalescence. JACC: Cardiovascular Imaging. 2015;8(1):106-8.
  • Burgoyne JR, Rudyk O, Cho H-J, Prysyazhna O, Hathaway N, Weeks A, Evans R, Ng T, Schröder K, Brandes RP, Shah AM, Eaton P .  Deficient angiogenesis in redox-dead Cys17Ser PKARI [alpha] knock-in mice. Nature communications. 2015;6.
  • Chen D, Xia M, Hayford C, Tham E-L, Semik V, Hurst S, Chen Y, Tam HH, Pan J, Wang Y, Tan X, Lan H-Y, Shen H, Kakkar VV, Xu Q, McVey JH, Dorling A.  Expression of Human Tissue Factor Pathway Inhibitor on Vascular Smooth Muscle Cells Inhibits Secretion of Macrophage Migration Inhibitory Factor and Attenuates Atherosclerosis in ApoE−/− Mice. Circulation. 2015;131(15):1350-60.
  • Chen Z, Sohal M, Sammut E, Child N, Jackson T, Claridge S, Cooklin M, O'Neill M, Wright M, Gill J.  Focal But Not Diffuse Myocardial Fibrosis Burden Quantification Using Cardiac Magnetic Resonance Imaging Predicts Left Ventricular Reverse Modeling Following Cardiac Resynchronization Therapy. Journal of Cardiovascular Electrophysiology. 2015.
  • Chen Z, Sohal M, Voigt T, Sammut E, Tobon-Gomez C, Child N, Jackson T, Shetty A, Bostock J, Cooklin M, O'Neill M, Wright M, Murgatroyd F, Gill J, Carr-White G, Chiribiri A, Schaeffter T, Razavi R, Rinaldi CA.  Myocardial tissue characterization by cardiac magnetic resonance imaging using T1 mapping predicts ventricular arrhythmia in ischemic and non–ischemic cardiomyopathy patients with implantable cardioverter-defibrillators. Heart Rhythm. 2015;12(4):792-801.
  • Child N, Bishop MJ, Hanson B, Coronel R, Opthof T, Boukens BJ, Walton RD, Efimov IR, Bostock J, Hill Y.  An activation-repolarization time metric to predict localized regions of high susceptibility to reentry. Heart Rhythm. 2015;12(7):1644-53.
  • Cubbon RM, Ruff N, Groves D, Eleuteri A, Denby C, Kearney L, Ali N, Walker AMN, Jamil H, Gierula J, Gale CP, Batin PD, Nolan J, Shah AM, Fox KAA, Sapsford RJ, Witte KK, Kearney MT.  Ambulatory heart rate range predicts mode-specific mortality and hospitalisation in chronic heart failure. Heart. 2015.
  • Epstein S, Willemet M, Chowienczyk PJ, Alastruey J.  Reducing the number of parameters in 1D arterial blood flow modeling: less is more for patient-specific simulations. American Journal of Physiology-Heart and Circulatory Physiology. 2015;309(1):H222-H34.
  • Hoefer IE, Steffens S, Ala-Korpela M, Bäck M, Badimon L, Bochaton-Piallat M-L, Boulanger CM, Caligiuri G, Dimmeler S, Egido J, Evans PC, Guzik T, Kwak BR, Landmesser U, Mayr M, Monaco C, Pasterkamp G, Tuñón J, Weber C; ESC Working Group Atherosclerosis and Vascular Biology.  Novel methodologies for biomarker discovery in atherosclerosis. European Heart Journal. 2015;36(39):2635-42.
  • Hyde ER, Behar JM, Claridge S, Jackson T, Lee AW, Remme EW, Sohal M, Plank G, Razavi R, Rinaldi CA, Niederer SA.  Beneficial Effect on Cardiac Resynchronization From Left Ventricular Endocardial Pacing Is Mediated by Early Access to High Conduction Velocity Tissue: Electrophysiological Simulation Study. Circ Arrhythm Electrophysiol. 2015;8(5):1164-72.
  • Iqbal MB, Khamis R, Ilsley C, Mikhail G, Crake T, Firoozi S, Kalra S, Knight C, Archbold A, Lim P, Mathur A, Meier P, Rakhit RD, Redwood S, Whitbread M, Bromage D, Rathod K, Jones DA, Wragg A, Dalby M, MacCarthy P, Malik IS.  Time-Trend Analyses of Bleeding and Mortality After Primary Percutaneous Coronary Intervention During Out of Working Hours Versus In-Working Hours: An Observational Study of 11 466 Patients. Circulation: Cardiovascular Interventions. 2015;8(6):e002206.
  • Kapustin AN, Chatrou MLL, Drozdov I, Zheng Y, Davidson SM, Soong D, Furmanik M, Sanchis P, De Rosales RTM, Alvarez-Hernandez D, Shroff R, Yin X, Muller K, Skepper JN, Mayr M, Reutelingsperger CP, Chester A, Bertazzo S, Schurgers LJ, Shanahan CM.  Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion. Circulation Research. 2015;116(8):1312-23.
  • Kaudewitz D, Skroblin P, Bender LH, Barwari T, Willeit P, Pechlaner R, Sunderland NP, Willeit K, Morton A, Armstrong PC.  Association of MicroRNAs and YRNAs with Platelet Function. Circulation Research. 2015:CIRCRESAHA. 114.305663.
  • Kohl T, Weninger G, Zalk R, Eaton P, Lehnart SE.  Intensity matters: Ryanodine receptor regulation during exercise. Proceedings of the National Academy of Sciences. 2015;112(50):15271-2.
  • Manou-Stathopoulou V, Goodwin CD, Patterson T, Redwood SR, Marber MS, Williams RP.  The effects of cold and exercise on the cardiovascular system. Heart. 2015:heartjnl-2014-306276.
  • Marciniak A, Marciniak M, Chiribiri A, Claridge S, Ramos V, Rajani R.  Multimodality Imaging of Extensive Caseating Intramyocardial Calcification Secondary to Lymphoma. Circulation: Cardiovascular Imaging. 2015;8(4):e002750.
  • Marjot J, Liebetrau C, Goodson RJ, Kaier T, Weber E, Heseltine P, Marber MS.  The development and application of a high-sensitivity immunoassay for cardiac myosin–binding protein C. Translational Research. 2015.
  • Mason GM, Lowe K, Melchiotti R, Ellis R, de Rinaldis E, Peakman M, Heck S, Lombardi G, Tree TIM.  Phenotypic Complexity of the Human Regulatory T Cell Compartment Revealed by Mass Cytometry. Journal of Immunology. 2015;195(5):2030-7.
  • Murakawa T, Yamaguchi O, Hashimoto A, Hikoso S, Takeda T, Oka T, Yasui H, Ueda H, Akazawa Y, Nakayama H, Taneike M, Misaka T, Omiya S, Shah AM, Yamamoto A, Nishida K, Ohsumi Y, Okamoto K, Sakata Y, Otsu K.  Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation. Nat Commun. 2015;6:7527.
  • Nabeebaccus A, Hafstad A, Eykyn T, Yin X, Brewer A, Zhang M, Mayr M, Shah A.  Cardiac-targeted NADPH oxidase 4 in the adaptive cardiac remodelling of the murine heart. The Lancet. 2015;385:S73.
  • Okonko DO, Shah AM.  Heart failure: Mitochondrial dysfunction and oxidative stress in CHF. Nature Reviews: Cardiology. 2015;12(1):6-8.
  • Patterson T, Webb I, Redwood SR.  Percutaneous Luminal Reconstruction of Giant Saphenous Vein Graft Aneurysm. JACC: Cardiovascular Interventions. 2015;8(9):e141-e2.
  • Shah AM.  Parsing the Role of NADPH Oxidase Enzymes and Reactive Oxygen Species in Heart Failure. Circulation. 2015;131(7):602-4.
  • Sinha MD, Keehn L, Milne L, Sofocleous P, Chowienczyk PJ.  Decreased Arterial Elasticity in Children With Nondialysis Chronic Kidney Disease Is Related to Blood Pressure and Not to Glomerular Filtration Rate. Hypertension. 2015;66(4):809-15.
  • Smyrnias I, Zhang X, Zhang M, Murray TV, Brandes RP, Schröder K, Brewer AC, Shah AM.  Nicotinamide Adenine Dinucleotide Phosphate Oxidase-4–Dependent Upregulation of Nuclear Factor Erythroid–Derived 2-Like 2 Protects the Heart During Chronic Pressure Overload. Hypertension. 2015;65(3):547-53.
  • Zampetaki A, Mayr M.  Sweet Dicer Impairment of Micro-RNA Processing by Diabetes. Circulation Research. 2015;117(2):116-8.
  • Zhang M, Prosser BL, Bamboye MA, Gondim ANS, Santos CX, Martin D, Ghigo A, Perino A, Brewer AC, Ward CW, Hirsch E, Lederer WJ, Shah AM.  Contractile Function During Angiotensin-II Activation: Increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban Phosphorylation. Journal of the American College of Cardiology. 2015;66(3):261-72.

2014

  • Arri S, Ryan M, Redwood S, Marber M.  Mental stress-induced myocardial ischaemia. Heart. 2016:heartjnl-2014-307306.
  • Aubdool AA, Graepel R, Kodji X, Alawi KM, Bodkin JV, Srivastava S, Gentry C, Heads R, Grant AD, Fernandes ES, Bevan S, Brain SD. TRPA1 is essential for the vascular response to environmental cold exposure. Nat Commun. 2014;5:5732.
  • Bajwa A, Wesolowski R, Patel A, Saha P, Ludwinski F, Smith A, Nagel E, Modarai B. Assessment of Tissue Perfusion in the Lower Limb Current Methods and Techniques Under Development. Circ-Cardiovasc Imag. 2014;7(5):836-43.
  • Bratis K, Chiribiri A, Hussain T, Krasemann T, Henningsson M, Phinikaridou A, Mavrogeni S, Botnar R, Nagel E, Razavi R, Greil G. Abnormal myocardial perfusion in Kawasaki disease convalescence. JACC Cardiovasc Imaging. 2015;8(1):106-8.
  • De Silva K, Lumley M, Kailey B, Alastruey J, Guilcher A, Asrress KN, Plein S, Marber M, Redwood S, Perera D. Coronary and microvascular physiology during intra-aortic balloon counterpulsation. JACC Cardiovasc Interv. 2014;7(6):631-40.
  • Di Bernardini E, Campagnolo P, Margariti A, Zampetaki A, Karamariti E, Hu Y, Xu Q. Endothelial lineage differentiation from induced pluripotent stem cells is regulated by microRNA-21 and transforming growth factor beta2 (TGF-beta2) pathways. J Biol Chem. 2014;289(6):3383-93.
  • Eaton P, Shah AM. Preface for redox signalling in the cardiovascular system. J Mol Cell Cardiol. 2014;73:1.
  • Fok H, Guilcher A, Brett S, Jiang BY, Li Y, Epstein S, Alastruey J, Clapp B, Chowienczyk P. Dominance of the Forward Compression Wave in Determining Pulsatile Components of Blood Pressure Similarities Between Inotropic Stimulation and Essential Hypertension. Hypertension. 2014;64(5):1116-+.
  • Fok H, Guilcher A, Li Y, Brett S, Shah A, Clapp B, Chowienczyk P. Augmentation Pressure Is Influenced by Ventricular Contractility/Relaxation Dynamics Novel Mechanism of Reduction of Pulse Pressure by Nitrates. Hypertension. 2014;63(5):1050-5.
  • Fu H, Kishore M, Gittens B, Wang G, Coe D, Komarowska I, Infante E, Ridley AJ, Cooper D, Perretti M, Marelli-Berg FM. Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation. Nat Commun. 2014;5:3436.
  • Goedeke L, Salerno A, Ramirez CM, Guo L, Allen RM, Yin X, Langley SR, Esau C, Wanschel A, Fisher EA, Suarez Y, Baldan A, Mayr M, Fernandez-Hernando C. Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice. EMBO Mol Med. 2014;6(9):1133-41.
  • Henningsson M, Greil GF, Burch M, Hussain T, Taylor AM, Muthurangu V, Botnar RM, Dedieu N. Coronary Magnetic Resonance Angiography in Heterotopic Heart Transplant Recipient. Circulation. 2014;129(13):1453-5.
  • Khawaja MZ, Cafferkey C, Rajani R, Redwood S, Cunningham D. Cardiac complications and manifestations of chemotherapy for cancer. Heart. 2014;100(14):1133-40.
  • Khawaja MZ, Williams R, Hung J, Arri S, Asrress KN, Bolter K, Wilson K, Young CP, Bapat V, Hancock J, Thomas M, Redwood S. Impact of preprocedural mitral regurgitation upon mortality after transcatheter aortic valve implantation (TAVI) for severe aortic stenosis. Heart. 2014;100(22):1799-803.
  • Lunt A, Desai SR, Wells AU, Hansell DM, Mushemi S, Melikian N, Shah AM, Thein SL, Greenough A. Pulmonary function, CT and echocardiographic abnormalities in sickle cell disease. Thorax. 2014;69(8):746-51.
  • Martin D, Li Y, Yang J, Wang G, Margariti A, Jiang Z, Yu H, Zampetaki A, Hu Y, Xu Q, Zeng L. Unspliced X-box-binding protein 1 (XBP1) protects endothelial cells from oxidative stress through interaction with histone deacetylase 3. J Biol Chem. 2014;289(44):30625-34.
  • Mayr M, Lee R, Kaudewitz D, Zampetaki A, Channon KM. Effects of heparin on temporal microRNA profiles. J Am Coll Cardiol. 2014;63(9):940-1.
  • Murdoch CE, Chaubey S, Zeng L, Yu B, Ivetic A, Walker SJ, Vanhoutte D, Heymans S, Grieve DJ, Cave AC, Brewer AC, Zhang M, Shah AM. Endothelial NADPH oxidase-2 promotes interstitial cardiac fibrosis and diastolic dysfunction through proinflammatory effects and endothelial-mesenchymal transition. J Am Coll Cardiol. 2014;63(24):2734-41.
  • Myat A, Redwood SR, Gersh BJ, Yellon DM, Marber MS. Diabetes, incretin hormones and cardioprotection. Heart. 2014;100(19):1550-61.
  • Peterfi Z, Toth ZE, Kovacs HA, Lazar E, Sum A, Donko A, Sirokmany G, Shah AM, Geiszt M. Peroxidasin-like protein: a novel peroxidase homologue in the human heart. Cardiovasc Res. 2014;101(3):393-9.
  • Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, Santos CX, Thet S, Mori E, Kinter MT, Rindler PM, Zacchigna S, Mukherjee S, Chen DJ, Mahmoud AI, Giacca M, Rabinovitch PS, Aroumougame A, Shah AM, Szweda LI, Sadek HA. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell. 2014;157(3):565-79.
  • Ribeiro Ede A, Jr., Pinotsis N, Ghisleni A, Salmazo A, Konarev PV, Kostan J, Sjoblom B, Schreiner C, Polyansky AA, Gkougkoulia EA, Holt MR, Aachmann FL, Zagrovic B, Bordignon E, Pirker KF, Svergun DI, Gautel M, Djinovic-Carugo K. The structure and regulation of human muscle alpha-actinin. Cell. 2014;159(6):1447-60.
  • Sag CM, Mallwitz A, Wagner S, Hartmann N, Schotola H, Fischer TH, Ungeheuer N, Herting J, Shah AM, Maier LS, Sossalla S, Unsold B. Enhanced late INa induces proarrhythmogenic SR Ca leak in a CaMKII-dependent manner. J Mol Cell Cardiol. 2014;76:94-105.
  • Skroblin P, Mayr M. "Going long": long non-coding RNAs as biomarkers. Circ Res. 2014;115(7):607-9.
  • Smillie S-J, King R, Kodji X, Outzen E, Pozsgai G, Fernandes E, Marshall N, de Winter P, Heads RJ, Dessapt-Baradez C, Gnudi L, Sams A, Shah AM, Siow RC, Brain SD. An Ongoing Role of α-Calcitonin Gene–Related Peptide as Part of a Protective Network Against Hypertension, Vascular Hypertrophy, and Oxidative Stress. Hypertension. 2014;63(5):1056-62.
  • Stegemann C, Pechlaner R, Willeit P, Langley SR, Mangino M, Mayr U, Menni C, Moayyeri A, Santer P, Rungger G, Spector TD, Willeit J, Kiechl S, Mayr M. Lipidomics profiling and risk of cardiovascular disease in the prospective population-based Bruneck study. Circulation. 2014;129(18):1821-31.
  • Stubbert D, Prysyazhna O, Rudyk O, Scotcher J, Burgoyne JR, Eaton P. Protein kinase G Ialpha oxidation paradoxically underlies blood pressure lowering by the reductant hydrogen sulfide. Hypertension. 2014;64(6):1344-51.
  • Timpson NJ, Walter K, Min JL, Tachmazidou I, Malerba G, Shin SY, Chen L, Futema M, Southam L, Iotchkova V, Cocca M, Huang J, Memari Y, McCarthy S, Danecek P, Muddyman D, Mangino M, Menni C, Perry JRB, Ring SM, Gaye A, Dedoussis G, Farmaki AE, Burton P, Talmud PJ, Gambaro G, Spector TD, Smith GD, Durbin R, Richards JB, Humphries SE, Zeggini E, Soranzo N, Consortium UK. A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans. Nature Communications. 2014;5.
  • Wagner S, Dantz C, Flebbe H, Azizian A, Sag CM, Engels S, Mollencamp J, Dybkova N, Islam T, Shah AM, Maier LS. NADPH oxidase 2 mediates angiotensin II-dependent cellular arrhythmias via PKA and CaMKII. J Mol Cell Cardiol. 2014;75:206-15.
  • Willeit P, Kiechl S, Kronenberg F, Witztum JL, Santer P, Mayr M, Xu Q, Mayr A, Willeit J, Tsimikas S. Discrimination and net reclassification of cardiovascular risk with lipoprotein(a): prospective 15-year outcomes in the Bruneck Study. J Am Coll Cardiol. 2014;64(9):851-60
  • Wong MS, Leisegang MS, Kruse C, Vogel J, Schurmann C, Dehne N, Weigert A, Herrmann E, Brune B, Shah AM, Steinhilber D, Offermanns S, Carmeliet G, Badenhoop K, Schroder K, Brandes RP. Vitamin D promotes vascular regeneration. Circulation. 2014;130(12):976-86.
  • Zampetaki A, Attia R, Mayr U, Gomes RSM, Phinikaridou A, Yin XK, Langley SR, Willeit P, Lu RF, Fanshawe B, Fava M, Barallobre-Barreiro J, Molenaar C, So PW, Abbas A, Jahangiri M, Waltham M, Botnar R, Smith A, Mayr M. Role of miR-195 in Aortic Aneurysmal Disease. Circulation Research. 2014;115(10):857-U141.

2013

  • Bellsham-Revell HR, Tibby SM, Bell AJ, Witter T, Simpson J, Beerbaum P, Anderson D, Austin CB, Greil GF, Razavi R.  Serial magnetic resonance imaging in hypoplastic left heart syndrome gives valuable insight into ventricular and vascular adaptation.  J Am Coll Cardiol. 2013 Feb 5; 61(5): 561-70.
  • Cullup T, Kho AL, Dionisi-Vici C, Brandmeier B, Smith F, Urry Z, Simpson MA, Yau S, Bertini E, McClelland V, Al-Owain M, Koelker S, Koerner C, Hoffmann GF, Wijburg FA, ten Hoedt AE, Curtis Rogers R, Manchester D, Miyata R, Hayashi M, Said E, Soler D, Kroisel PM, Windpassinger C, Filloux FM, Al-Kaabi S, Hertecant J, Del Campo M, Buk S, Bodi I, Goebel HH, Sewry CA, Abbs S, Mohammed S, Josifova D, Gautel M & Jungbluth H.  Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy.  Nature Genetics. 2013 Jan;45(1):83-7. 
  • Karamariti E, Margariti A, Winker B, Wang X, Hong X, Baban D, Ragoussis J, Huang Y, Han JJ, Wong MM, Sag CM, Shah AM, Hu Y, Xu Q. Smooth muscle cells differentiated from reprogrammed embryonic lung fibroblasts through DKK3 signalling are potent for tissue engineering of vascular grafts. Circ Res. 2013; in press. 
  • Pernigo S, Lamprecht A, Steiner RA, Dodding MP.  Structural basis for kinesin-1:cargo recognition.  Science. 2013 Apr 19;340(6130):356-9. 
  • Willeit P, Zampetaki A, Dudek K, Kaudewitz D, King AS, Kirkby NS, Crosby-Nwaobi R, Prokopi M, Drozdov I, Langley S, Sivaprasad S, Markus HS, Mitchell JA, Warner T, Kiechl S and Mayr M.  Circulating MicroRNAs as Novel Biomarkers for Platelet Activation.  Circ Res.  2013 Feb 15;112(4):595-600.

2012

  • Barallobre-Barreiro J, Didangelos A, Schoendube FA, Drozdov I, Yin X, Fernández-Caggiano M, Willeit P, Puntmann VO, Aldama-López G, Shah AM, Doménech N, Mayr M. Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia-reperfusion injury. Circulation. 2012; 125(6):789-802
  • Cecelja M, Jiang B, Spector TD, Chowienczyk P. Progression of central pulse pressure over 1 decade of aging and its reversal by nitroglycerin a twin study. J Am Coll Cardiol. 2012; 59(5):475-83.
  • Martin DE, Felice De Nicola G, Marber MS. New therapeutic targets in cardiology: p38 alpha mitogen-activated protein kinase for ischemic heart disease. Circulation. 2012;126(3):357-68.
  • Hautvast G, Chiribiri A, Zarinabad N, Schuster A, Breeuwer M, Nagel E. Myocardial blood flow quantification from MRI by deconvolution using an exponential approximation basis. IEEE Trans Biomed Eng. 2012 Jul;59(7):2060-7.
  • Haworth RS, Stathopoulou K, Candasamy AJ, Avkiran M. Neurohormonal regulation of cardiac histone deacetylase 5 nuclear localization by phosphorylation-dependent and phosphorylation-independent mechanisms. Circ Res. 2012;110(12):1585-95.
  • Jogiya R, Kozerke S, Morton G, De Silva K, Redwood S, Perera D, Nagel E, Plein S. Validation of dynamic 3-dimensional whole heart magnetic resonance myocardial perfusion imaging against fractional flow reserve for the detection of significant coronary artery disease. J Am Coll Cardiol. 2012; 60(8):756-65
  • Knowles AC, Irving M, Sun YB. Conformation of the Troponin Core Complex in the Thin Filaments of Skeletal Muscle during Relaxation and Active Contraction. J Mol Biol. 2012 Aug 3;421(1):125-37.
  • Makowski MR, Preissel A, von Bary C, Warley A, Schachoff S, Keithan A, Cesati RR, Onthank DC, Schwaiger M, Robinson SP, Botnar RM. Three-Dimensional Imaging of the Aortic Vessel Wall Using an Elastin-Specific Magnetic Resonance Contrast Agent. Invest Radiol. 2012 Jul;47(7):438-444
  • Oka T, Hikoso S, Yamaguchi O, Taneike M, Takeda T, Tamai T, Oyabu J, Murakawa T, Nakayama H, Nishida K, Akira S, Yamamoto A, Komuro I, Otsu K. Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature. 2012 May 10;485(7397):251-5.
  • Peel SA, Morton G, Chiribiri A, Schuster A, Nagel E, Botnar RM. Dual Inversion-Recovery MR Imaging Sequence for Reduced Blood Signal on Late Gadolinium-enhanced Images of Myocardial Scar. Radiology. 2012 Jul;264(1):242-9.
  • Phinikaridou A, Andia ME, Protti A, Indermuehle A, Shah A, Smith A, Warley A, Botnar RM. Noninvasive MRI evaluation of endothelial permeability in murine atherosclerosis using an albumin-binding contrast agent.Circulation. 2012; 126(6):707-19.
  • Prysyazhna O, Rudyk O, Eaton P. Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension. Nat Med. 2012;18(2):286-90.
  • Rudyk O, Prysyazhna O, Burgoyne JR, Eaton P. Nitroglycerin fails to lower blood pressure in redox-dead Cys42Ser PKG1α knock-in mouse. Circulation. 2012;126(3):287-95.
  • Schröder K, Zhang M, Benkhoff S, Mieth A, Pliquett R, Kosowski J, Kruse C, Luedike P, Michaelis UR, Weissmann N, Dimmeler S, Shah AM, Brandes RP. Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase. Circ Res. 2012; Apr 27;110(9):1217-25.
  • Schuster A, Hedström E, Blauth C, Marber MS, Nagel E, Carr-White G. Ruptured aneurysm of the sinus of valsalva insights from magnetic resonance first-pass myocardial perfusion imaging. J Am Coll Cardiol. 2012; 59 (5):538.
  • Weissmann N, Sydykov A, Kalwa H, Storch U, Fuchs B, y Schnitzler MM, Brandes RP, Grimminger F, Meissner M, Freichel M, Offermanns S, Veit F, Pak O, Krause KH, Schermuly RT, Brewer AC, Schmidt HHHW, Seeger W, Shah AM, Gudermann T, Ghofrani HA, Dietrich A. Activation of the TRPC6 channel is essential for lung ischemia–reperfusion injury. Nature Commun. 2012;3:649
  • Zampetaki A, Mayr M. MicroRNAs in vascular and metabolic disease. Circ Res. 2012 Feb 3;110(3):508-22. Review.
  • Zampetaki A, Willeit P, Tilling L, Drozdov I, Prokopi M, Renard JM, Mayr A,Weger S, Schett G, Shah A, Boulanger CM, Willeit J, Chowienczyk PJ, Kiechl S,Mayr M. Prospective study on circulating microRNAs and risk of myocardial infarction. J Am Coll Cardiol. 2012;60(4):290-9.
  • Zhang M, Takimoto E, Lee DI, Santos CX, Nakamura T, Hsu S, Jiang A, Nagayama T, Bedja D, Yuan Y, Eaton P, Shah AM, Kass DA. Pathological cardiac hypertrophy alters intracellular targeting of PDE5 from nitric oxide synthase-3 to natriuretic peptide signaling. Circulation. 2012; 21;126(8):942-51.

2011

  • Bazigou E*, Lyons OT*, Smith A, Venn GE, Cope C, Brown NA, Makinen T. Venous valve formation and maintenance in mice are controlled by genes regulating lymphangiogenesis J Clin Invest 2011; 121:2984-2992

  • Berry DJ, Ma Y, Ballinger JR, Tavaré R, Koers A, Sunassee K, Zhou T, Nawaz S, Mullen GED, Hider RC, Blower PJ. Efficient bifunctional gallium-68 chelators for positron emission tomography: tripodal tris(hydroxypyridone) ligands. Chem Commun, 2011; 47:7068 - 7070.
  • Braun T, Gautel M. Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis. Nat Rev Mol Cell Biol. 2011;12(6):349-61.
  • Cecelja M, Jiang B, Bevan L, Frost ML, Spector TD, Chowienczyk PJ. Arterial stiffening relates to arterial calcification but not to noncalcified atheroma in women. A twin study. J Am Coll Cardiol. 2011 9;57(13):1480-6
  • Charles RL, Burgoyne JR, Mayr M, Weldon SM, Hubner N, Dong H, Morisseau C, Hammock BD, Landar A, Eaton P. Redox regulation of soluble epoxide hydrolase by 15-deoxy-delta-prostaglandin J2 controls coronary hypoxic vasodilation. Circ Res. 2011; 108(3):324-34.
  • Chiribiri A, Conte MR, Bonamini R, Gaita F, Nagel E. Late gadolinium enhancement and sudden cardiac death in hypertrophic cardiomyopathy. J Am Coll Cardiol. 2011; 57(12):1402.
  • Didangelos A, Yin X, Mandal K, Saje A, Smith A, Xu Q, Jahangiri M, Mayr M. Extracellular matrix composition and remodeling in human abdominal aortic aneurysms: a proteomics approach. Mol Cell Proteomics. 2011; 10(8):M111.008128.
  • Jansen CH, Perera D, Makowski MR, Wiethoff AJ, Phinikaridou A, Razavi RM, Marber MS, Greil GF, Nagel E, Maintz D, Redwood S, Botnar RM. Detection of intracoronary thrombus by magnetic resonance imaging in patients with acute myocardial infarction. Circulation. 2011; 124(4):416-24.
  • Kapustin A, Davies JD, Reynolds JL, McNair R, Jones GT, Sidibe A, Schurgers LJ, Skepper JN, Proudfoot D, Mayr M, Shanahan CM. Calcium regulates key components of vascular smooth muscle cell-derived matrix vesicles to enhance mineralization. Circ Res. 2011; 109:e1-e12.
  • Lockie T, Ishida M, Perera D, Chiribiri A, De Silva K, Kozerke S, Marber M, Nagel E, Rezavi R, Redwood S, Plein S. High-resolution magnetic resonance myocardial perfusion imaging at 3.0-Tesla to detect hemodynamically significant coronary stenoses as determined by fractional flow reserve. J Am Coll Cardiol. 2011; 57(1):70-5. Erratum in: J Am Coll Cardiol. 2011 Mar 29; 57(13):1501.
  • Makowski MR, Wiethoff AJ, Blume U, Cuello F, Warley A, Jansen CH, Nagel E, Razavi R, Onthank DC, Cesati RR, Marber MS, Schaeffter T, Smith A, Robinson SP, Botnar RM. Assessment of atherosclerotic plaque burden with an elastin-specific magnetic resonance contrast agent. Nat Med. 2011; 17(3):383-8.
  • Ratti J, Rostkova E, Gautel M, Pfuhl M. "Structure and interactions of myosin binding protein domain C0: Cardiac specific regulation of myosin at its neck?, J Biol Chem. 2011; 286, 12650-12658
  • Schwaeble WJ, Lynch NJ, Clark JE, Marber M, Samani NJ, Ali YM, Dudler T, Parent B, Lhotta K, Wallis R, Farrar CA, Sacks S, Lee H, Zhang M, Iwaki D, Takahashi M, Fujita T, Tedford CE, Stover CM. Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury. Proc Natl Acad Sci USA. 2011; 108(18):7523-8.
  • Shah AM, Mann DL. In search of new therapeutic targets and strategies for heart failure: recent advances in basic science. Lancet. 2011; 378:704-712.
  • Stegeman C, Drozdov I, Shalhoub J, Humphries J, Ladroue C, Didangelos A, Baumert M, Allen M, Davies AH, Monaco C, Smith A, Xu Q, Mayr M. Comparative lipidomics profiling of human atherosclerotic plaques. Circ Cardiovasc Genet. 2011; 4:232-42.
  • Tiburcy M, Didié M, Boy O, Christalla P, Doeker S, Naito H, Karikkineth BC, El-Armouche A, Grimm M, Nose M, Eschenhagen T, Zieseniss A, Katschinksi D, Hamdani N, Linke WA, Yin X, Mayr M, Zimmermann WH. Terminal differentiation, advanced organotypic maturation, and modeling of hypertrophic growth in engineered heart tissue. Circ Res. 2011; 109:1105-14.
  • Xiao Q, Wang G, Yin X, Luo Z, Margariti A, Zeng L, Mayr M, Ye S, Xu Q. Chromobox protein homolog 3 is essential for stem cell differentiation to smooth muscles in vitro and in embryonic arteriogenesis Arterioscler Thromb Vasc Biol. 2011; 31(8):1842-52.

2010

  • Didangelos A, Yin X, Mandal K, Baumert M, Jahangiri M, Mayr M. Proteomic characterization of extracellular space components in the human aorta. Mol Cell Proteomics. 2010;9:2048-2062

  • Kleinschnitz C, Grund H, Wingler K, Armitage ME, Jones E, Mittal M, Barit D, Schwarz T, Geis C, Barthe K, Schumann M, Kraft P, Herrmann A, Meuth SG, Stoll G, Meurer S, Becker L, Gailus-Durner V, Fuchs H, Klopstock T, de Angelis MH, Jandeleit-Dahm K, Shah AM, Weissmann N, Schmidt HHHW. Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration. PLoS Biology. 2010;8:e1000479. doi:10.1371/journal.pbio.1000479
  • Kumphune S, Bassi R, Jacquet S, Sicard P, Clark JE, Verma S, Avkiran M, O'Keefe SJ, Marber MS. A chemical genetic approach reveals that p38alpha MAPK activation by diphosphorylation aggravates myocardial infarction and is prevented by the direct binding of SB203580. J Biol Chem. 2010;285:2968-2975.
  • Lockie T, Ishida M, Perera D, Chiribiri A, De Silva K, Kozerke S, Marber M, Nagel E, Rezavi R, Redwood S, Plein S. High-resolution magnetic resonance myocardial perfusion imaging at 3.0-Tesla to detect hemodynamically significant coronary stenoses as determined by fractional flow reserve. J Am Coll Cardiol. 2010;57:70-75.
  • Margariti A, Zampetaki A, Xiao Q, Zhou B, Karamariti E, Martin D, Yin X, Mayr M, Li H, Zhang Z, De Falco E, Hu Y, Cockerill G, Xu Q, Zeng L. Histone deacetylase 7 controls endothelial cell growth through modulation of beta-catenin. Circ Res. 2010;106:1202-1211.
  • Niu XL, Madamanchi NR, Vendrov AE, Tchivilev I, Rojas M, Madamanchi C, Brandes RP, Krause KH, Humphries J, Smith A, Burnand KG, Runge MS. Nox activator 1: a potential target for modulation of vascular reactive oxygen species in atherosclerotic arteries. Circulation. 2010;121:549-59.
  • Nordsletten DA, Kay DA, Smith NP. A non-conforming monolithic finite element method for problems of coupled mechanics. Computational Physics. 2010;20:7571-7593.
  • Nordsletten D, McCormick M, Kilner PJ, Hunter P, Kay D, Smith NP. Fluid–solid coupling for the investigation of diastolic and systolic human left ventricular function. Int J Numerical Methods Biomed Engineering. 2010; doi: 10.1002/cnm.1405
  • Pepe AE, Xiao Q, Zampetaki A, Zhang Z, Kobayashi A, Hu Y, Xu Q. Crucial role of Nrf3 in smooth muscle cell differentiation from stem cells. Circ Res. 2010;106:870-879.
  • Pernigo S, Fukuzawa A, Bertz M, Holt M, Rief M, Steiner RA, Gautel M. Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex. Proc Natl Acad Sci USA. 2010;107:2908–2913.
  • Tzifa A, Krombach GA, Krämer N, Krüger S, Schütte A, von Walter M, Schaeffter T, Qureshi S, Krasemann T, Rosenthal E, Schwartz CA, Varma G, Buhl A, Kohlmeier A, Bücker A, Günther RW, Razavi R. Magnetic resonance-guided cardiac interventions using magnetic resonance-compatible devices: a preclinical study and first-in-man congenital interventions. Circ Cardiovasc Interv. 2010;3:585-592.
  • Wang L, Zheng J, Du Y, Huang Y, Li J, Liu B, Liu CJ, Zhu Y, Gao Y, Xu Q, Kong W, Wang X. Cartilage oligomeric matrix protein maintains the contractile phenotype of vascular smooth muscle cells by interacting with alpha(7)beta(1) integrin. Circ Res. 2010;106:514-525.
  • Warren DT, Ragnauth CD, Liu Y, McNair R, Tajsic T, Figg N, Shroff R, Skepper J, Shanahan CM. Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging. Circulation. 2010;121:2200-2210.
  • Yin X, Cuello F, Mayr U, Hao Z, Hornshaw M, Ehler E, Avkiran M, Mayr M. Proteomics analysis of the cardiac myofilament subproteome reveals dynamic alterations in phosphatase subunit distribution. Mol Cell Proteomics. 2010;9:497-509.
  • Zampetaki A, Kiechl S, Drozdov I, Willeit P, Mayr U, Prokopi M, Mayr A, Weger S, Oberhollenzer F, Bonora E, Shah A, Willeit J, Mayr M. Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type II diabetes. Circ Res. 2010;107:810-817.
  • Zampetaki A, Zeng L, Margariti A, Xiao X, Li H, Zhang Z, Pepe AE, Wang G, deFalco E, Cockerill G, Mason J, Hu Y, Xu Q. Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow. Circulation. 2010;121:132-142.
  • Zhang M, Brewer AC, Schröder K, Santos CX, Grieve DJ, Wang M, Anilkumar N, Yu B, Dong X, Walker SJ, Brandes RP, Shah AM. NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis. Proc Natl Acad Sci USA. 2010;107:18121-18126.

2009

  • Boubertakh R, Prieto C, Batchelor PG, Uribe S, Atkinson D, Eggers H, Sorensen TS, Hansen MS, Razavi RS, Schaeffter T . Whole-Heart imaging using undersampled radial phase encoding (RPE) and iterative sensitivity encoding (SENSE) reconstruction. Magn Reson Med. 2009;62:1331-1337.

  • Cecelja M, Jiang B, McNeill K, Kato B, Ritter J, Spector T, Chowienczyk P. Increased wave reflection rather than central arterial stiffness is the main determinant of raised pulse pressure in women and relates to mismatch in arterial dimensions: a twin study. J Am Coll Cardiol. 2009;54:695-703.
  • Charles RL, Burgoyne JR, Mayr M, Weldon SM, Hubner N, Dong H, Morisseau C, Hammock BD, Landar AL, Eaton P. Redox regulation of soluble epoxide hydrolase by 15-deoxy-{delta}-Prostaglandin J2 controls coronary hypoxic vasodilation. Circ Res. 2010 Dec 16. [Epub ahead of print]
  • Chaturvedi RR, Herron T, Simmons R, Shore D, Kumar P, Sethia B, Chua F, Vassiliadis E, Kentish JC. Passive stiffness of myocardium from congenital heart disease and implications for diastole. Circulation. 2010;121:979-88.
  • Ding L, Dong L, Chen X, Zhang L, Xu X, Ferro A, Xu B. Increased expression of integrin-linked kinase attenuates left ventricular remodeling and improves cardiac function after myocardial infarction. Circulation. 2009;120:764-773.
  • Jacquet S, Yin X, Sicard P, Clark J, Kanaganayagam GS, Mayr M, Marber MS. Identification of cardiac myosin-binding protein C as a candidate biomarker of myocardial infarction by proteomics analysis. Mol Cell Proteomics. 2009;8:2687-2699
  • Laxton RC, Hu Y, Duchene J, Zhang F, Zhang Z, Leung KY, Xiao Q, Scotland RS, Hodgkinson CP, Smith K, Willeit J, López-Otín C, Simpson IA, Kiechl S, Ahluwalia A, Xu Q, Ye S. A role of matrix metalloproteinase-8 in atherosclerosis. Circ Res. 2009;105:921-929.
  • Lockie T, Nagel E, Redwood S, Plein S. Use of cardiovascular magnetic resonance imaging in acute coronary syndromes. Circulation.2009;119:1671-1681.
  • Prokopi M, Pula G, Mayr U, Devue C, Gallagher J, Xiao Q, Boulanger CM, Westwood N, Urbich C, Willeit J, Steiner M, Breuss J, Xu Q, Kiechl S, Mayr M. Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures. Blood. 2009;114:723-732.
  • Pula G, Mayr U, Evans C, Prokopi M, Vara DS, Yin X, Astroulakis Z, Xiao Q, Hill J, Xu Q, Mayr M. Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures. Circ Res. 2009;104:32-40.
  • Seddon M, Melikian N, Dworakowski R, Shabeeh H, Jiang B, Byrne J, Casadei B, Chowienczyk P, Shah AM. Effects of neuronal nitric oxide synthase on human coronary artery diameter and blood flow in vivo.Circulation. 2009;119:2656-2662.
  • Tavaré R, Torres Martin De Rosales R, Blower PJ, Mullen GE. Efficient site-specific radiolabeling of a modified C2A domain of synaptotagmin I with [99mTc(CO)3]+: a new radiopharmaceutical for imaging cell death. Bioconjug Chem. 2009;20:2071-2081
  • Zeng L, Zampetaki A, Margariti A, Pepe AE, Alam S, Martin D, Xiao Q, Wang W, Jin ZG, Cockerill G, Mori K, Li YS, Hu Y, Chien S, Xu Q. Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow. Proc Natl Acad Sci USA. 2009;106:8326-8331.

2008

  • Ababou A, Rostkova E, Mistry S, Le MC, Gautel M, Pfuhl M. Myosin binding protein C positioned to play a key role in regulation of muscle contraction: structure and interactions of domain C1. J Mol Biol. 2008;384:615-630.

  • Avkiran M, Rowland AJ, Cuello F, Haworth RS. Protein kinase D in the cardiovascular system: emerging roles in health and disease. Circ Res.2008 Feb 1;102(2):157-63. Review.
  • Dworakowski R, Walker S, Momin A, Desai J, El-Gamel A, Wendler O, Kearney MT, Shah AM. Reduced nicotinamide adenine dinucleotide phosphate oxidase-derived superoxide and vascular endothelial dysfunction in human heart failure. J Am Coll Cardiol. 2008;51:1349-1356.
  • Foteinos G, Hu Y, Xiao Q, Metzler B, Xu Q. Rapid endothelial turnover in atherosclerosis-prone areas coincides with stem cell repair in apolipoprotein E-deficient mice. Circulation. 2008;117:1856-1863.
  • Ewence AE, Bootman M, Roderick HL, Skepper JN, McCarthy G, Epple M, Neumann M, Shanahan CM, Proudfoot D. Calcium phosphate crystals induce cell death in human vascular smooth muscle cells: a potential mechanism in atherosclerotic plaque destabilization. Circ Res.2008;103:e28-e34.
  • Mayr M, Zampetaki A, Sidibe A, Mayr U, Yin X, De Souza AI, Chung YL, Madhu B, Quax PH, Hu Y, Griffiths JR, Xu Q. Proteomic and metabolomic analysis of smooth muscle cells derived from the arterial media and adventitial progenitors of apolipoprotein E-deficient mice. Circ Res.2008;102:1046-1056.
  • Nishino Y, Webb IG, Davidson SM, Ahmed AI, Clark JE, Jacquet S, Shah AM, Miura T, Yellon DM, Avkiran M, Marber MS. Glycogen synthase kinase-3 inactivation is not required for ischemic preconditioning or postconditioning in the mouse. Circ Res. 2008;103:307-314.
  • Saurin AT, Durgan J, Cameron AJ, Faisal A, Marber MS, Parker PJ. The regulated assembly of a PKCepsilon complex controls the completion of cytokinesis. Nat Cell Biol. 2008;10:891-901.
  • Seddon MD, Chowienczyk PJ, Brett SE, Casadei B, Shah AM. Neuronal nitric oxide synthase regulates basal microvascular tone in humans in vivo.Circulation. 2008;117:1991-1996.
  • Shroff RC, McNair R, Figg N, Skepper JN, Schurgers L, Gupta A, Hiorns M, Donald AE, Deanfield J, Rees L, Shanahan CM. Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis. Circulation. 2008;118:1748-1757.
  • Snabaitis AK, Cuello F, Avkiran M. Protein kinase B/Akt phosphorylates and inhibits the cardiac Na+/H+ exchanger NHE1. Circ Res. 2008;103:881-890.
  • Xu Q. Stem cells and transplant arteriosclerosis. Circ Res. 2008;102:1011-1024
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