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Muscle: Form and Function

Julien Ochala

Biography

Dr Julien Ochala joined the Centre for Human & Applied Phsiological Sciences (CHAPS) in 2013 and is a Lecturer in Human Physiology

Research Interests

The focus of our lab is to understand the molecular and cellular mechanisms underlying muscle weakness in a number of diseases. Our primary interest is congenital myopathies and muscular dystrophies. However, we also collaborate with other research groups to study muscle weakness in response to cancer and ageing. We hope that our work will provide sufficient knowledge to identify drug targets and design novel therapeutic interventions.

Methodologies

In our lab, we use human and animal muscle samples, and apply techniques ranging from single molecule biophysics to muscle cell physiology and from X-ray diffraction to high-resolution confocal microscopy.

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Publications and Funding

Key Publications:

Ochala J, Iwamoto H, Larsson L, Yagi N. (2010) A myopathy-linked tropomyosin mutation severely alters thin filament conformational changes during activation. Proc Natl Acad Sci USA. 107: 9807-9812

 Gokhin DS, Ochala J, Domenighetti AA, Fowler VM. (2015) Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle. Development. 142: 4351-4362.

 Lindqvist J, Levy Y, Pati-Alam A, Hardeman EC, Gregorevic P, Ochala J (2016) Modulating myosin restores muscle function in a mouse model of nemaline myopathy. Ann Neurol. 79: 717–725.

A full list fo publications can be found here

We currently hold a project grant from the Medical Research Council UK. However, your donation means we can speed up our research on muscle weakness and the design of efficient therapeutic interventions. For more information please contact Dr Julien Ochala (julien.ochala@kcl.ac.uk).

Click here for funding information.

Group Members

Dr Julien Ochala (Principal Investigator)

Dr Jacob Ross (Post Doctoral Researcher)

Yotam Levy (PhD student - 1st supervsor)

Openings

We are looking for talented graduate students and postdoctoral research associates. For more information please contact Dr Julien Ochala (julien.ochala@kcl.ac.uk).

julien
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