Lab work and members
The research undertaken in the Collins lab is two-fold:
- There is an increasing interest in the role of iron in controlling biological processes. Following many years researching the role of iron on intracellular infections including salmonella and tuberculosis, Helen’s lab has diversified to understand how iron metabolism influences the immune response, particularly in long-term inflammatory conditions such as rheumatoid arthritis. A collaboration with Professor Robert Hider, an iron chelation chemist, has led to the use of novel iron chelators which have potential as therapeutic agents in such conditions. A more recent collaboration with Professor Alberto Sanchez-Fueyo is investigating the role of iron in liver disease and transplantation. This research has been funded by Arthritis Research UK and the Medical Research Council.
- To investigate nanoparticle interactions with macrophages. This work is in collaboration with Dr Lea Ann Dailey and colleagues in the Institute of Pharmaceutical Sciences at KCL. This work is funded by grants from the EPSRC and more recently funding has been obtained from the NC3Rs to investigate the induction of foamy macrophages following inhalation of pharmacologic agents.