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Lab work and members

Cope lab

The Cope lab seeks to understand at the molecular and cellular level pathways of T cell activation and differentiation that promote autoimmunity, and which contribute to the persistence of chronic immune and inflammatory responses. 

More specifically, we are interested in investigating the impact of altered T cell antigen receptor signalling (TCR) thresholds (both inherited and acquired) on:

  • pathways of T helper cell activation, differentiation and cytokine gene expression,
  • pathways of cell migration, and
  • the mechanisms through which T lymphocytes regulate innate immune responses in vivo.

Among translational research projects, major effort is being made to understand the immunological basis of sustained clinical remission in patients with rheumatoid arthritis.

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