The Cope lab seeks to understand at the molecular and cellular level pathways of T cell activation and differentiation that promote autoimmunity, and which contribute to the persistence of chronic immune and inflammatory responses.
More specifically, we are interested in investigating the impact of altered T cell antigen receptor signalling (TCR) thresholds (both inherited and acquired) on:
- pathways of T helper cell activation, differentiation and cytokine gene expression,
- pathways of cell migration, and
- the mechanisms through which T lymphocytes regulate innate immune responses in vivo.
Among translational research projects, major effort is being made to understand the immunological basis of sustained clinical remission in patients with rheumatoid arthritis.