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Phagocytes play an important role in directly killing microbes but also control the development of adaptive immunity. This is important because this activity underlie our capacity to respond better upon antigen challenge. Dendritic cells are sentinel cells of the immune system that phagocyte foreign antigens and activate or silence T lymphocytes. As such, dendritic cells have a paramount importance in triggering protective (anti-infectious or anti-tumoral immunity) as well as deleterious immune responses (auto-immunity). We aim at understanding the dynamics of dendritic cell populations and how they present antigens to T cells. This knowledge is key to the development of innovative therapeutic or prophylactic intervention aiming at inhibiting (in the context of auto-immune diseases) or stimulating (in the context of vaccination or immunotherapy) immune responses.
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