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Leonie Taams

Selected recent publications

  • Taams LS, Steel KJA, Srenathan U, Burns LA, Kirkham BW. IL-17 in the immunopathogenesis of spondyloarthritis. Nature Rev Rheumatol. 2018 Jul 13. doi: 10.1038/s41584-018-0044-2. [Epub ahead of print].
  • Roberts CA, Durham L, Fleskens V, Evans HG and Taams LS. TNF blockade maintains an IL-10+ phenotype in human effector CD4+ and CD8+ T cells. Frontiers Immunol 2017 Feb 15;8:157. doi: 10.3389/fimmu.2017.00157
  • Rajasekhar M, Olsson AM, Steel KJ, Georgouli M, Ranasinghe U, Brender Read C, Frederiksen KS and Taams LS. MicroRNA-155 contributes to enhanced resistance to apoptosis in monocytes from patients with rheumatoid arthritis. J Autoimmunity 2017 Jan 21. pii: S0896-8411(17)30025-2. doi: 10.1016/j.jaut.2017.01.002.
  • Walter GJ, Fleskens V, Frederiksen KS, Rajasekhar M, Menon B, Gerwien JG, Evans HG, Taams LS. Phenotypic, Functional, and gene expression profiling of peripheral CD45RA+ and CD45RO+ CD4+CD25+CD127(low) Treg cells in patients with chronic rheumatoid arthritis. Arthritis Rheumatol. 2016 Jan;68(1):103-16. doi: 10.1002/art.39408.
  • Evans HG, Roostalu U, Walter GJ, Gullick NJ, Frederiksen KS, Roberts CA, Sumner J, Baeten DL, Gerwien JG, Cope AP, Geissmann F, Kirkham BW, Taams LS. TNF-α blockade induces IL-10 expression in human CD4+ T cells. Nature Communications. 2014;5:3199. doi: 10.1038/ncomms4199.
  • Menon B, Gullick NJ, Walter GJ, Rajasekhar M, Garrood T, Evans HG, Taams LS*, Kirkham BW* (*equal contribution). IL-17+CD8+ T-cells are enriched in the joints of patients with psoriatic arthritis and correlate with disease activity and joint damage progression. Arthritis Rheumatol. 2014;66(5):1272-81. doi: 10.1002/art.38376.
  • Evans HG, Gullick NJ, Kelly S, Pitzalis C, Lord GM, Kirkham BW and Taams LS. In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses. Proc Natl Acad Sci USA 2009, 106:6232-6237.
  • Tiemessen MM, Jagger AL, Evans HG, van Herwijnen M, John S, and Taams LS. CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages. Proc Natl Acad Sci USA 2007, 104:19446-19451.
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