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Susan John

Susan John BSc Hons, ARCS, PhD

SusanJohnSenior Lecturer

Module Lead in Molecular Immunology and Admissions tutor for MSc Immunology

Lectures on the following modules and courses: Undergraduate modules in Molecular Immunology, Cellular Interactions in the Immune System and Immunology of Human Disease, and postgraduate courses; MSc Immunology, and MSc in Medical Immunology

Tel: +44 (0) 20 7848 9614
email: 
susan.john@kcl.ac.uk

 

Research Interests

Susan John’s lab studies TCR and cytokine-induced signalling mechanisms that regulate T cell activation and differentiation in healthy T cells and the dysregulation of these molecular mechanisms in inflammatory diseases (Crohns), autoimmunity (GPA) and cancer (CTCL). We perform basic research to identify and characterise cytokine and TCR-induced signalling proteins and their regulators using molecular and cellular biological techniques. Proteins of interest that may have relevance in disease are further investigated in human translational studies to understand their importance in disease pathology or in animal models in collaboration with other labs. 

Recent Publications

  • Afzali B and John S. Janus kinases (JAK)-STAT Signaling pathway. Inflammatory Mediators Section. Encyclopedia of Inflammatory Diseases. Ed. Michael J Parnham. Springer Pub. In press 2015.
  • Rani A, Greenlaw R, Runglall M, Jurcevic S, John S. (2014) FRA2 is a STAT5 target gene regulated by IL-2 in human CD4 T cells. PLoS ONE 9(2): e90370.
  • Afzali B, Mitchell PJ, Edozie FC et al. and John S* Lombardi G. CD161 expression characterizes a sub-population of human regulatory T cells that produces IL-17 in a STAT3 dependent manner. (2013) EJI, 32:2043. *corresponding author and shared senior author.
  • Povoleri G, Scottà C, Nova-Lamperti E, John S, Lombardi G, Afzali B. Thymic versus induced regulatory T cells – who regulates the regulators? (2013), Frontiers in Immunology 169: 1-22.
  • Rani A, Afzali B, Kelly A, Tewolde-Berhan L, Hackett M, Kanhere A.S, Pedroza-Pacheco I, Bowen H, Jurcevic S, Jenner R.G., Cousins, D., Ragheb J.A., Lavender Pand John S. IL-2 regulates expression of c-maf in human CD4 T cells. 2011. J. Immunol. 187(7): 3721-9.
  • Afzali, B, Mitchell, P, Lechler, R.I., John, S and Lombardi, G.  Induction of interleukin-17 production by regulatory T cells. (2010), Clinical and Experimental Immunology, 159 (2): 120-130.
  • Stevens CN, Simeone A-M, John S, Ahmed Z, Lucherini O, Baldari CT, & Ladbury JE. T Cell Receptor Early Signalling Complex Activation in Response to Interferon-α Receptor Stimulation. 2010, Biochemical Journal. 2010; 428(3):429-437.
  • Kaneko K, Smetana-Just U, Matsui M, Young AR, John S, Norval M, and Walker SL.  cis-Urocanic acid Initiates Gene Transcription in Primary Human Keratinocytes. (2008) The Journal of Immunology, 181:217-224.
  • Tiemessen MM, Evans HG, Jagger AL, John S and Taams LS. CD4+CD25+FoxP3+regulatory T cells induce alternative activation of human monocytes/macrophages. (2007) PNAS, 104: 19446-19451.
  • Schuster, B., Hendry, L., Byers, H., Lynham, S.F., Ward, M.A., and John S. Purification and identification of the Stat5 protease in myeloid cells. (2007)  Biochem.J. 404, 81-87.
  • Tiemessen MM, Mitchell TJ, Hendry L, Whittaker SJ, Taams LS, and John S. Lack of Suppressive CD4+CD25+FoxP3+ T cells in Advanced Stages of Primary Cutaneous T Cell Lymphoma. (2006). Journal of Invest. Dermatol. 126: 2217-2223.
  •  Mitchell, T and John, S.  STAT signaling and T cell Lymphomas. (2005) Immunology, 114; 301-312.
  • Meyer, T., Hendry, L., Begitt A., John, S* and Vinkemeier, U*. A single  residue modulates tyrosine dephosphorylation, oligomerization, and nuclear accumulation of Stat transcription factors. (2004) J. Biol Chem. Apr 30;279(18):18998-9007. *shared correspondence.
  • Hendry, L and John, S. Regulation of STAT signaling by proteolytic processing. (2004) Eur. J. Biochem 271:4613-4620.
  • Mitchell, T.J., Whittaker, S.J., and John, S. Dysregulated expression of C-terminally truncated Stat5 and loss of Stat5-dependent gene expression in Sezary Syndrome. (2003) Cancer Research 63, 9048-9054.
  • McDyer, J.F., Li Z., John S., Yu, W., Wu, C.Y., Ragheb, J.A. IL-2 receptor blockade inhibits late, but not early, IFN-gamma and CD40 ligand expression in human T cells: disruption of both IL-12-dependent and -independent pathways of IFN-gamma production. (2002) J Immunol. 1;169 (5):2736-46.
  • Soldaini, E., John, S., Moro, S., Bollenbacher, J., Schindler, U., and Leonard, W.J.  (2000).  DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals an unexpectedly large repertoire of tetrameric Stat5a binding sites.  Mol. Cell. Biol. 20, 389-401.
  • Zhu, M-H, John, S, Berg, M, and Leonard, W.J. (1999).  Functional association of Nmi with Stat5 and Stat1 in IL-2 and IFN-gamma-mediated signaling.  Cell, 96, 121-130.
  • John, S., Vinkemeier, U., Soldaini, E., Darnell, J. E. Jr., and Leonard W. J. (1999).  The significance of tetramerization in promoter recruitment by Stat5.  Mol.Cell.Biol., 19, 1910-1918. 
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