Lecturer in Immunology
Fellow of the Higher Education Academy
Lectures on: Undergraduate modules in Molecular Immunology; postgraduate modules in Cellular Interactions in the Immune System, and Immune disorders and infection for MSc Immunology.
Chair of the exam board for MSc Medical Immunology.
Tel: +44 (0) 20 7848 9608
The newborn child is highly susceptible to infection, and this susceptibility is further increased in those born prematurely. Yet, despite this, neonatal immunology is conspicuously understudied. My research focuses on understanding immune cell development and function in the human neonate. We have identified a novel T cell effector function in neonates that contrasts with T cell biology in adults and that also conflicts with the view that lymphocytes in newborns are anti-inflammatory. This has provoked a number of further questions that are the basis of my research going forward.
How do these cells develop normally and is their dysregulation associated with infection or carcinogenesis ie T cell acute lymphocytic leukaemia and thymoma?
What is the fate of these neonatal T cells?
Are there other features of the developing immune system that determine how infants respond to infection?
These studies will promote our understanding of the developing immune system in infants. This may help to identify infants more at risk from inflammation and infection and subsequently reduce infant mortality - a current NHS target and huge health burden.
DL Gibbons, P. Fleming, A.Virasami, M-L Michel, N. Sebire, K. Costeloe,R. Carr, N. Klein, A. Hayday (2014): Interleukin-8 (CXCL8) Production is the signatory T cell effector function of human newborn infants. Nature Medicine 20 (10): 1206-1210
Battersby AJ and Gibbons DL. The gut mucosal immune system in the neonatal period. (2013) Pediatric Allergy and Immunology 24 (5):414-21
DL Gibbons,S. F.Y Haque, T. Silberzahn, K. Hamilton, C. Langford, P. Ellis, R. Carr and A.C. Hayday. (2009) Neonatal human gd cells are highly active yet exhibit functional defects in premature babies. Eur J Immunol 39:1794-1806
DL Gibbons, L. Abeler-Dorner, T. Raine, I.Y. Hwang, A. Jandke, M. Wencker, L. Deban, C. Rudd, P. Irving, J. Kehrl and A.C. Hayday. (2011) Regulator of G protein signalling-1 (RGS1) selectively regulates gut T cell trafficking and colitic potential J. Immunol187 (5) : 2067-71
Gibbons, DL , Haque, Y, Copestake, S, Archer, A, Leggat, J, Noble, A, Smith, AL, Hayday, AC (2009) Infection with a self limiting natural gut pathogen reduces lung allergy Mucosal Immunology 2:144-155
Das A, Rouault-Pierre K, Kamdar S, Gomez-Tourino I, Wood K, Donaldson I, Mein CA, Bonnet D, Hayday AC, Gibbons DL. Adaptive from Innate: Human IFN-γ+CD4+ T Cells Can Arise Directly from CXCL8-Producing Recent Thymic Emigrants in Babies and Adults. J Immunol. (2017) 119(5):1696-1705