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DiMeglio

Cutaneous Immunology Group

Dr Paola Di Meglio, PhD, MsPharm            

Lecturer in Cutaneous Immunology

Research 

  • The etiopathogenesis of complex inflammatory skin conditions, such as psoriasis and atopic dermatitis, with a particular focus on the interplay between genetic and environmental factors leading to dysregulated immune responses. 
  • Biomarkers discovery in skin inflammatory disease.

At the heart of the Cutaneous Immunology Lab is an integrated research approach combining basic and translational research, including in vitro and ex vivo cellular and molecular assays, multi-omics ex vivo analysis of human clinical samples, as well as animal models of diseases.

Specific projects ongoing in the group include:

  • Functional immunomonitoring of psoriasis patients undergoing biologics treatment for the identification of immune determinants of response to therapy (PSORT;  MRC-funded consortium)
  • Multidimensional phenotypic analysis of patients with skin inflammatory diseases (BIODIP;  BRC funded)
  • The study of the skin microbiome in psoriasis (MRC Clinical Research Training Fellowship)
  • The study of the transcription factor and environmental sensor Aryl Hydrocarbon Receptor (AhR) and its role in inflammatory skin disease psoriasis and atopic dermatitis (in collaboration with Dr. Stockinger, The Francis Crick Institute).

Biography

Dr. Di Meglio received her PhD in Pharmacology from the University of Naples Federico II. she was Visiting Postgraduate Fellow in the Section of Immunobiology at Yale University, Research Associate at St. John’s Institute of Dermatology, and Senior Investigator Scientist at the Francis Crick Institute, formerly MRC National Institute for Medical Research (NIMR) in Mill Hill.  In March 2017 she become Lecturer in Cutaneous Immunology at St John’s Institute of Dermatology. Dr Di Meglio is also Visiting Scientist at the Francis Crick Institute.

Dr Di Meglio’s research interest is in the etiopathogenesis of complex inflammatory skin conditions, with a particular focus on the interplay between genetic, environmental and immune factors. She has also an interest in pharmacogenomics and biomarkers discovery. She identified and functionally characterized the IL23R R381Q gene variant conferring protection to psoriasis and other inflammatory diseases. Her more recent work has uncovered the beneficial role the transcription factor and environmental sensor AhR in skin inflammation.

Dr Di Meglio has been the recipient of the European Society for Dermatological Research (EASDR)/Celgene Award, and of the British Society for Investigative Dermatology (BSID) Young Investigator Award, both in 2014.  She is Section Editor in Dermatology and Skin Immunology for Pharmacological Research. Dr Di Meglio has given over 25 invited lectures, including at the World Congress of Dermatology in 2015.

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