Professor John McGrath's Group
Professor John McGrath
Professor of Molecular Dermatology
Head of St John’s Institute of Dermatology
The main focus of research is improving understanding of the molecular and cellular basis of inherited skin diseases and to try to translate new findings into clinical benefits for patients.The group has a track record in identifying the molecular basis of inherited skin diseases.Key recent discoveries include the first gene mutations in several forms of epidermolysis bullosa, Kindler syndrome, lipoid proteinosis, and primary cutaneous amyloidosis. The Group also discovered the first inherited disorders of desmosomes.
Translational research involves close liaison with the Robin Eady National Diagnostic Epidermolysis Bullosa Laboratory and clinical services for individuals with epidermolysis bullosa provided by the Guy’s and St Thomas’ NHS Foundation Trust.
The Group has pioneered fetal skin biopsy and DNA-based methods for the prenatal diagnosis of inherited skin diseases and performed the first successful preimplantation genetic diagnosis analyses.
The Group is currently working with several centres around the world to develop new cell-based, gene and protein therapies for individuals with epidermolysis bullosa and other inherited skin diseases.