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Dr Ivo Lieberam

Senior Lecturer Ivo-Lieberam

Centre for Stem Cells & Regenerative Medicine 
King's College London 
28th Floor, Tower Wing
Guy's campus
Great Maze Pond
London SE1 9RT

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Biography

Ivo completed his Ph.D. with Dr Irmgard Foerster and Prof Klaus Rajewsky (Institute for Genetics, University of Cologne, Germany). In this thesis, he investigated the role of chemokines in the communication between antigen-presenting cells and T lymphocytes, a key event in the initiation of immune responses. In 2000, Ivo changed the direction of his research to Developmental Neuroscience and joined the laboratory of Prof Thomas M. Jessell (Columbia University, New York, USA) as postdoctoral fellow. In the Jessell group, he began to study the role of the chemokine receptor Cxcr4 in CNS exit point choice, a crucial early step in motor axon guidance. Together with Dr Hynek Wichterle, he also developed a method which allows the direct differentiation of motor neurons from embryonic stem cells, a technology which is now widely used to study the development and physiology of motor neurons. Ivo became an independent investigator at King’s College London in 2009, and joined the Centre for Stem Cells and Regenerative Medicine in July 2015.

Research interests

The main focus of my research is the question how pluripotent stem cell technology can be harnessed to understand the function and dysfunction of neural circuits which control motor behaviour, and how stem cell-derived tissue can be used to regenerate neuromuscular circuits in adult mammalian animal models and, ultimately, in human patients. To this end, my group embarked on projects aimed at i) assembling neuromuscular circuits from stem cell-derived, defined cell populations to study normal development and degenerative disease processes in vitro and ii) restoring muscle function affected by neuromuscular disease with a new type of stem cell-based optogenetic pacemaker device.

Job opportunities

Any vacant posts within the Centre for Stem Cells and Regenerative Medicine are advertised on the King's College London HireWire website
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