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Research Projects

Heart failure

Heart failureOur research team is a collaboration between the clinical Cardiology Department at Guy’s and St Thomas’ NHS Trust and the Division of Imaging Sciences and Biomedical Engineering of King’s College London.

Our main research interest is in the field of Cardiac resynchronisation therapy (CRT). This is an established treatment for improving symptoms in patientswith congestive heart failure (CHF) by left ventricular (LV)pacing. CRT can help to improve LVfunction in patients with heart failure if those regionsof the myocardium, which are most compromised by electromechanical dyssynchrony, can be identified and effectively stimulated. There still remains, however, a significant rate of up to 30% of patients who do not respond to treatment. Reasons for lack of benefit can be related to the inability of identifyingand effectively stimulating those regions of myocardium, whichare most compromised by electromechanical dyssynchrony.

Our work is aimed at addressing CRT non response; we use novel imaging and electro-anatomical mapping to better understand non responders and to develop novel techniques to overcome the problem. This includes endocardial pacing, multisite LV pacing and image guidance with MRI to direct LV lead placement.

Work in our department has helped us better understand the mechanisms of non response. We are about to undertake a large scale multi-centre trial using advanced image guidance for CRT in collaboration with a German centre.

We also work closely with the Biomedical Engineering team to develop computerised biophysical models to predict response to CRT and aid patient selection.

Our other area of interest is ventricular arrhythmia in the Heart failure population. We are investigating the use of novel MRI imaging to predict ICD therapy in patients. We are also performing computerised modelling of such arrhythmias.

The aims of the group are to develop new treatments to benefit patients with heart failure and arrhythmias.

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