The Beavil Group
The Beavil group aims to identify the basic cell and molecular mechanisms underlying the development of allergic sensitisation and chronic airway inflammation. Our skills lie in the fields of molecular biology, spectroscopy and molecular biophysics, techniques that enable us to study molecular size, shape, structure and interactions both in solution and in in vitro cell culture systems.
Asthma is a chronic condition characterised by a narrowing of the bronchial tubes, swelling of the bronchial tube lining, and mucous secretion that can block the airway, making breathing difficult. These effects are caused by the persistence of inflammation often identifiably caused by an allergy. Our work is underpinned by the Asthma UK funded lectureship held by AJB.
Most of our work is focused on the biophysical characterisation of immunoglobulin E (IgE) and its interactions with its receptors (see references below). This work forms the theoretical basis of a major series of translational projects aimed at developing novel small-molecule inhibitors of the IgE-FcR1 interaction. Our work overlaps and complements that of Professors Brian Sutton (Structural Biology) and Hannah Gould (Immunology).