The Csikász-Nagy Group
Group Leader: Dr Attila Csikász-Nagy
The Csikász-Nagy group investigates the dynamics of cell to cell interactions and molecular regulatory networks by computational systems biology techniques. We build mathematical models that capture the dynamics of the molecular networks which regulate cell cycle, cell polarity and cell growth in yeast cells. Use these models as a basis to investigate the orthologous systems in higher eukaryotes (plants, mammals). On a higher level we build models of cell to cell interaction networks to investigate how local extracellular signals influence tissue topology. We merge these in multi-scale models that capture the behaviour of individual cells and their local interactions with neighbouring cells.
(Left) Protein-protein interaction network of cell cycle (red), cell polarity (blue) and cytokinesis (yellow) regulators in fission yeast. We investigate which proteins are important to link these functions. (Middle) Model of game-like cell to cell interactions of co-operators (blue) and cheaters (red) in an epithelia-like cell network. (Right) Positive and negative feedbacks between the key regulators of cell cycle regulation in budding yeast cells.