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Krause Group

Dr Matthias Krause

Matthias-Krause

Group leader

Email: matthias.krause@kcl.ac.uk
Tel: +44 (0) 20 7848 6959
Fax: +44 (0) 20 7848 6435

Biography

  • Lecturer, Randall Division and Department of Anatomy, King's College London, 2010 onwards
  • Group Leader, Randall Division, King's College London, 2004 onwards
  • Postdoctoral Research Associate, Massachusetts Institute of Technology, Cambridge, MA, USA, 2000-2004
  • Ph.D. Cell Biology, German Research Center for Biotechnology, Braunschweig, Germany 1999
  • License as German pharmacist 1995
  • Degree in Pharmaceutical Sciences, University Carolo-Wilhelmina, Braunschweig, Germany 1994

Publications

  • Ah-Lai Law, Anne Vehlow, Maria Kotini, Lauren Dodgson, Daniel Soong, Eric Theveneau, Cristian Bodo, Eleanor Taylor, Christel Navarro, Upamali Perera, Magdalene Michael, Graham A. Dunn, Daimark Bennett, Roberto Mayor, and Matthias Krause (2013) Lamellipodin and the Scar/WAVE complex cooperate to regulate cell migration in vivo. Journal of Cell Biology, Journal of Cell Biology 203(4), 673-689.
  • Anne Vehlow, Daniel Soong, Gema Vizcay-Barrena, Cristian Bodo, Ah-Lai Law, Upamali Perera, and Matthias Krause (2013) Endophilin and Lamellipodin Cooperate to Regulate F-actin-dependent Endocytosis of the EGF-receptor. EMBO J 32, 2722-2734.
  • Michael, M., Vehlow, A., Navarro, C., Krause, M. (2010) c-Abl, Lamellipodin, and Ena/VASP proteins cooperate in dorsal ruffling of fibroblasts and axonal morphogenesis. Curr Biol, 20(9), 783-91. Times cited: 18
  • Schulze, S., Huang, G., Krause, M., Aubyn, D., Bolanoz Quinones, V.A., Schmidt, C.K., Mei, Y., Schmidt, O.G. (2010) Morphological differentiation of neurons on microtopographic substrates fabricated by rolled-up nanotechnology. Advanced Engineering Materials, 12(9), B558-64. Times cited: 14
  • Lyulcheva E. Taylor E. Michael M., Vehlow A., Tan S., Fletcher A., Krause M, Bennett D., (2008) Drosophila Pico and its mammalian ortholog Lamellipodin activate serum response factor and promote cell proliferation. Dev Cell 15, 680-690. Times cited: 13
  • Watanabe, N., Bodin, L., Pandey, M., Krause, M., Coughlin, S., Boussiotis, V.A., Ginsberg, M.H., Shattil, S.J. (2008). Mechanism and Consequences of Agonist-Induced Talin Recruitment to Platelet Integrin alphaIIb-beta3. J. Cell Biol. 181(7): 1211-22. Times cited: 61
  • Chang Ch., Adler C. E., Krause M., Clark S.G., Gertler F. B., Tessier-Lavigne M., Bargmann C.I. (2006) MIG-10/Lamellipodin and the lipid modulator AGE-1/PI3K promote axon guidance and outgrowth in response to Slit and netrin. Curr. Biol. 16(9):854-62.  Times cited: 68
  • Krause, M., Leslie, J.D., Stewart, M., Lafuente, E.M., Valderrama, F., Jagannathan, R., Strasser G.A., Rubinson D.A., Liu, H., Way, M., Yaffe, M.B., Boussiotis, V.A., Gertler, F.B. (2004). Lamellipodin, an  Ena/VASP ligand, is implicated the regulation of lamellipodial dynamics. Dev Cell. 7(4), 571-583. Times cited: 103
  • Lafuente*, E.M., van Puijenbroeck*, A.A., Krause, M., Carman, C.V., Freeman, G.J., Berezovskaya A., Constantine, E., Springer, T.A., Gertler, F.B., Boussiotis, V.A.. (2004). RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1 induced adhesion. Dev Cell. 7(4), 585-595. Times cited: 186
  • Lebrand, C., Dent, E.W., Strasser, G.A., Lanier, L.M., Krause, M., Svitkina, T.M., Borisy, G.G., Gertler, F.B. (2004) Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of Netrin-1. Neuron 42, 37-49. Times cited: 151
  • Bear*, J.E., Svitkina*, T.M., Krause, M., Schafer, D.A., Loureiro, J.J., Strasser, G.A., Maly, I.V., Chaga, O.Y., Cooper, J.A., Borisy, G.G., Gertler, F.B. (2002). Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility. Cell 109, 509-521.  Times cited: 450
  • Coppolino, M.G., Krause, M., Hagendorff, P., Monner, D.A., Trimble, W., Grinstein, S., Wehland, J., Sechi, A.S. (2001). Evidence for a molecular complex consisting of Fyb/SLAP, SLP-76, Nck, VASP and WASP that links the actin cytoskeleton to Fcgamma receptor signalling during phagocytosis. J. Cell Sci. 114, 4307-4318. Times cited: 104
  • Rottner*, K., Krause*, M., Gimona, M., Small, J.V., Wehland, J. (2001). Zyxin is not colocalized with vasodilator-stimulated phosphoprotein (VASP) at lamellipodial tips and exhibits different dynamics to vinculin, paxillin, and VASP in focal adhesions. Mol. Biol. Cell 12, 3103-3113. Times cited: 67
  • Krause, M., Sechi, S.A., Konradt, M., Monner, D., Gertler, F.B., and Wehland, J. (2000).
  • Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/Vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR)-signaling to the actin cytoskeleton. J. Cell Biol. 149, 181-194. Times cited: 200

* contributed equally to this paper

Reviews

  • Krause, M., Gautreau, A. (2014) Steering cell migration: lamellipodium dynamics and the regulation of directional persistence. Nat Rev Mol Cell Biol., 15(9), 577-90
  • Krause, M. (2011) Abl at the leading edge. Nat Rev Mol Cell Biol. 12(1):8.
  • Pula, G. and Krause, M. (2008) Role of Ena/VASP proteins in homeostasis and disease. Handb Exp Pharmacol. 2008; Vol 186: 39-65.
  • Krause, M., Dent, E., Bear, J.E., Loureiro, J.J. Gertler, F.B. (2003) Ena/VASP proteins: regulators of the actin cytoskeleton and cell migration. Annu. Rev. Cell Dev Biol. 19, 541-564. Times cited: 295
  • Krause, M., Bear, J.E., Loureiro, J.J., and Gertler, F.B. (2002). The Ena/VASP enigma.  J. Cell Sci. 115, 4721-4726. Times cited: 63
  • Bear, J.E., Krause, M., and Gertler, F.B. (2001). Regulating cellular actin assembly. Curr. Opin. Cell Biol. 13,158-166.

 

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