The Stramer Group
Group Leader: Dr Brian Stramer
Cell migration plays critical roles during both animal development and pathological processes, such as cancer metastasis. Despite this clinical significance most of our knowledge surrounding how cells move stems from in vitro assays of limited physiological relevance. To begin to extrapolate some of our in vitro understanding of cell motility to an in vivo scenario we are exploiting the embryonic developmental dispersal of Drosophila (fruit fly) macrophages (hemocytes). Much like human macrophages, these cells are crucial for innate immunity and are necessary for responses to infection and tissue damage. We have developed a number of microscopy techniques that allow us to image these cells migrating in vivo at a spatial and temporal resolution approaching what can be achieved from cells in culture. This attribute, along with genetic tractability of flies, enables us to examine the genes and cytoskeletal responses driving migratory processes within a living animal.
Work in our lab is supported by the Wellcome Trust and BBSRC
For more information on projects and job opportunities please see www.stramerlab.com