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Sun Group

Recent publications

  1.  Zhang X, Kampourakis T, Yan Z, Sevrieva I, Irving M & Sun Y-B. Distinct contributions of the thin and thick filaments to length-dependent activation in heart muscle. eLife, 2017; doi:10.7554/eLife.24081
  2.  Robertson IM, Pineda-Sanabria SE, Yan Z, Kampourakis T, Sun Y-B, Sykes BD & Irving M. Reversible covalent binding to cardiac troponin C by the Ca2+-sensitizer levosimendan. Biochemistry, 2016; 55:6032–6045. doi:10.1021/acs.biochem.6b00758
  3. Ochala J & Sun Y-B. Novel myosin-based therapies for congenital cardiac and skeletal myopathies. Journal of Medical Genetics 2016; doi:10.1136/jmedgenet-2016-103881
  4. Kampourakis T, Sun Y-B & Irving M. Myosin light chain phosphorylation enhances contraction of heart muscle via structural changes in both thick and thin filaments. Proceedings of the National Academy of Sciences 2016; 113:E3039-E3047. doi:10.1073/pnas.1602776113
  5. Pineda-Sanabria SE, Robertson IM, Sun Y-B, Irving M & Sykes BD. Probing the mechanism of cardiovascular drugs using a covalent levosimendan analog. Journal of Molecular and Cellular Cardiology 2016; 92:174-84. doi:10.1016/j.yjmcc.2016.02.003
  6. Robertson IM, Sevrieva I, Li MX, Irving M, Sun Y-B* & Sykes BD. The structural and functional effects of the familial hypertrophic cardiomyopathy-linked cardiac troponin C mutation, L29Q. Journal of Molecular and Cellular Cardiology 2015; 87:257-69. doi:10.1016/j.yjmcc.2015.08.017
  7.  Kampourakis T, Sun Y-B & Irving M. Orientation of the N- and C-terminal lobes of the myosin regulatory light chain in cardiac muscle. Biophysical Journal 2015; 108:304-14. doi:10.1016/j.bpj.2014.11.04
  8. Kampourakis T, Yan Z, Gautel M, Sun Y-B & Irving M. Myosin binding protein-C activates thin filaments and inhibits thick filaments in heart muscle cells. Proceedings of the National Academy of Sciences 2014; 111: 18763–8. doi:10.1073/pnas.1413922112
  9. Sevrieva I, Knowles AC, Kampourakis T & Sun Y-B. Regulatory domain of troponin moves dynamically during activation of cardiac muscle. Journal of Molecular and Cellular Cardiology 2014; 75:181-7. doi:10.1016/j.yjmcc.2014.07.015
  10. Fusi L, Brunello E, Sevrieva I, Sun Y-B & Irving M. Structural dynamics of troponin during activation of skeletal muscle. Proceedings of the National Academy of Sciences 2014; 111:4626-31. doi:10.1073/pnas.1321868111
  11. Knowles AC, Irving M & Sun Y-B. Conformation of the troponin core complex in the thin filaments of skeletal muscle during relaxation and active contraction. Journal of Molecular Biology 2012; 421:125-37. doi:10.1016/j.jmb.2012.05.005  
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