The Trentham Group
The Trentham group aims to decipher structural and kinetic details of biological processes, in real time, at the cellular level. We aim to understand these biological processes in the same molecular detail as we do for isolated individual components. To this end, we have an understanding of protein structures at atomic resolution and mechanisms of enzyme catalysing and regulating steps in metabolic pathways.
One of the main techniques we employ is the use of photolabile but biologically inert ‘caged’ compounds. Using caged ATP which can be released in microseconds within a muscle fibre, we can investigate both muscle contraction and regulation - both essential to all living animals. Disruption of either process can be the basis of many aspects of human disease and ageing.
Dr David Trentham, FRS (Visiting Professor)