Professor Steven Sacks
Professor Sacks is interested in the primitive set of defensive proteins making up the complement system, and the impact these may have on organ transplantation and cell replacement. This builds on the previous work of the laboratory showing that local production of complement proteins at the site of tissue stress or infection can potentially make or break the outcome of organ replacement.
A new initiative is tackling the way in which carbohydrates exposed by tissue stress trigger the complement cascade to exaggerate the type of injury caused by alteration of blood flow during transplant surgery (with Dr Wuding Zhou, King’s College London and Professor Wilhelm Schwaeble
, University of Leicester).
Developing new clinical aids out of basic laboratory findings forms a staple part of our research programme. We are building the capability for genetic prediction of transplant outcome and for imaging techniques that will allow us to visualise transplant organs under immune attack (with Professor Graham Lord
and Dr Gregg Mullen
, respectively, King's College London).
Dedication of our research to the precise targeting of therapeutic proteins against complement and clotting factors (with Dr Richard Smith
, and Dr Anthony Dorling
, King's College London) is enabling the clinical evaluation of a number of potential treatments.
A new package of work through the UK Regenerative Medicine Programme Immunology Hub (in collaboration with Professor Giovanna Lombardi
and Professor Fiona Watt
) examines the influence of the innate immune system on the ability of stem cells to differentiate, migrate and survive when hosted by the recipient. Professor Sacks
takes an active interest in the regulation and ethical practice of research, reflected in educational and research programmes of our transplant centre (with Professor Genevra Richardson
and Dr Antonia Cronin
, King's College London).
View Professor Steven Sacks' research profile