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Professor Wuding Zhou

Professor Wuding Zhou

MRC Centre for Transplantation
King’s College London
5th Floor, Tower Wing
Guy's Hospital
London SE1 9RT
Tel 0207 1881528
e-mail  wuding.zhou@kcl.ac.uk

Current appointment

Professor in Immunology


About Professor Wuding Zhou 

Wuding Zhou graduated from Huaxi Medical University in China in 1983 and gained a PhD in the department of Nephrology and Transplantation at Guy’s Hospital, London University in 1995. In the same department, she carried out 5 years post-doctoral research and subsequently became Lecturer in 2001 and Reader in immunology in 2009. Wuding has being working in the fields of complement and immunology since her PhD studies began. 

A list of Prof Zhou’s publications and reviews can be found on the PubMed website

Research interests

Wuding’s PhD and Post-doctoral studies involved the role of complement in renal disease and ischemia/reperfusion (IR) injury, which have identified the cells and components involved in intra-renal synthesis of complement and their association with renal diseases, ischemia/reperfusion injury and transplant rejection. These studies have led 28 publications including Lancet, JCI. Since becoming a Lecturer in 2001 and now Reader in Immunology at King’s College London, Wuding has focused her research on the role of complement as an important regulator of immune responses. Wuding is currently interested in the role of complement particularly C3a and C5a in immune regulation and trying to understand whether and how complement interacts with several pivotal cells of the immune system (e.g. antigen presenting cells, natural killer cells, macrophages and stem cells) participating in antimicrobial defence, cancer elimination, IR injury, transplant rejection, autoimmunity and tissue repair. Understanding of the interaction between complement and these cells may lead to the development of new (complement-based) pharmaceutical approaches. 

 

The major contributions of her group’s research to this field include the following discoveries or identifications:

• DCs, the most important antigen presenting cells (APCs) are able to synthesise a wide range of C proteins. (JI 2006, MI 2011)

• Local production and activation of complement is critical for the maintenance of APC function, thus generating efficient specific T cell responses. (Blood 2006, Blood 2008)

• Anaphylatoxins (C3a, C5a) acting on their receptors expressed on DCs is an important mechanism by which complement modulates adaptive immune responses. cAMP/PKA signalling is a major pathway through which C3a-C3aR or C5a-C5aR interaction modulates DC function. (Blood 2008, JI 2009, Immunobiology 2012)

• Predominant role for C5a in promoting renal IR injury. (JASN 2012)

• A contributory role for C5a receptor resulting in the rejection of organ transplants, lending support to a new therapeutic strategy to prevent rejection by blocking receptor signalling. (JASN 2010)

• A novel strategy of intragraft delivery of membrane-localising C regulator to increase the number of successful transplants in a pre-clinical model. (JASN 2006) 

• Complement and P-selectin-mediated pathways of renal IR injury are mutually independent, suggesting that complement and P-selectin pose two distinct targets for therapy (at intravascular and extravascular sites, respectively) clarifying future strategies for preventing transplant injury in clinical translation. (JASN 2004)

View Prof Wuding Zhou's Research Profile 


 

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