Research & Impact
Dr Chrysothemis Brown, Wellcome Trust Research Training Fellow in the Division of Transplantation Immunology & Mucosal Biology, has had details of her study relating to the regulation of immune responses by Vitamin A published in the journal Immunity.
Vitamin A deficiency is a major public health problem globally with significant morbidity and mortality due to infectious disease. The findings of the study have identified the mechanisms by which retinoic acid, the active metabolite of vitamin A, control Th1 cell mediated immunity and also unexpectedly showed that vitamin A signalling was also required to suppress harmful autoimmune inflammation driven by T-helper 17 cells suggesting a potential role for perturbed vitamin A signalling in the pathogenesis of autoimmune disease.
The full journal article Retinoic Acid Is Essential for Th1 Cell Lineage Stability and Prevents Transition to a Th17 Cell Program is available on the Immunity website.
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