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Liver Sciences

Group Lead

Professor Alberto Sanchez Fueyo

The department of Liver Studies is led by Professor Alberto Sanchez Fueyo and is based at the Denmark Hill campus of KCL.  The department which includes Professor Julia Wendon, Professor Richard Thompson, Dr Debbie Shawcross, Dr Yun Ma, Dr Emer Fitzpatrick, Dr Marc Martinez-Llordella and Dr Ivana Carey covers a wide range of research including the following major themes:

-Hepatocyte Biology: developing hepatocyte transplantation for children with liver-based metabolic disorders

-Liver Immunopathology: investigating immune mechanisms involved in autoimmune hepatitis; primary biliary cirrhosis; viral hepatitis; and acute liver failure

-Liver Molecular Genetics: investigating the molecular basis of cholestasis and bile formation

Research includes:

development of innovative therapy for liver disease, including new surgical techniques;

use of marginal livers and isolated human hepatocytes to increase the organ pool;

novel surgical and medical managements of biliary atresia;

liver gene therapy, cancer therapy by exploiting allogeneic immune recognition;

supportive management for liver failure, including the liver role in controlling growth hormone/insulin-like growth factor axis;

insulin resistance in chronic liver disease and acute liver failure; muscle and adrenal dysfunction in critically ill patients;

influence of cirrhotic cardiomyopathy and intrathoracic volume on renal function and haemodynamic status;

pathophysiology of cerebral edema;

impact of defective monocyte function on the outcome of liver failure; extra-corporeal liver support devices;

immunopathology of liver damage, including immuno pathogenic aspects of autoimmune and viral induced liver disease; rejection and tolerance in liver transplantation;

molecular basis of cholestasis and bile formation, including genetic characterisation of progressive familial intrahepatic cholestasis type 1 (BSEP deficiency), type 2 (PFC1 disease), type 3 (MDR3 deficiency), neonatal sclerosing cholangitis, intestinal microvillus atrophy


Professor Alberto Sanchez Fueyo
Prof Julia Wendon
Prof Richard Thompson
Dr Debbie Shawcross
Dr Yun Ma
Dr Emer Fitzpatrick
Dr Marc Martinez-Llordella
Dr Ivana Carey

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