King's College London is the leading research centre for HIV-associated kidney disease in the UK. Our interests include the clinical epidemiology of HIV-associated kidney disease and the effects of antiretroviral therapy on kidney function. We have described the clinical epidemiology of HIV-associated nephropathy (HIVAN) and acute, chronic and end-stage kidney disease in the UK.
In addition, we have recently described the value of baseline kidney function as predictor of kidney disease progression, the outcomes of kidney transplantation in HIV positive patients, and the clinical characteristics of patients with proteinuria and renal tubular dysfunction. We are currently conducting studies to examine the link between renal tubular dysfunction and bone demineralization and the effects of specific antiretrovirals on vitamin D homeostasis and bone.
Our work has informed the BHIVA guidelines for the routine investigation and monitoring of adult HIV-1-infected individuals and for the treatment of HIV-1 positive adults with antiretroviral therapy.